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The role of inflammatory cytokines as key modulators of neurogenesis

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)145-157
Number of pages13
JournalTrends in Neurosciences
Issue number3
Early online date8 Jan 2015
E-pub ahead of print8 Jan 2015
PublishedMar 2015


King's Authors


Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.

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