Research output: Contribution to journal › Article › peer-review
Original language | English |
---|---|
Pages (from-to) | 145-157 |
Number of pages | 13 |
Journal | Trends in Neurosciences |
Volume | 38 |
Issue number | 3 |
Early online date | 8 Jan 2015 |
DOIs | |
E-pub ahead of print | 8 Jan 2015 |
Published | Mar 2015 |
Borsini_Manuscript_Trends_in_Neurosciences
Borsini_Manuscript_Trends_in_Neurosciences.pdf, 957 KB, application/pdf
Uploaded date:21 Jun 2017
Version:Accepted author manuscript
Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.
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