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The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system

Research output: Contribution to journalReview article

Shuang Gu, Vladimir E. Shevchik, Rosie Shaw, Richard W. Pickersgill, James A. Garnett

Original languageEnglish
Pages (from-to)1255-1266
Number of pages12
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Issue number10
Publication statusPublished - 1 Oct 2017

King's Authors


Many Gram-negative commensal and pathogenic bacteria use a type II secretion system (T2SS) to transport proteins out of the cell. These exported proteins or substrates play a major role in toxin delivery, maintaining biofilms, replication in the host and subversion of host immune responses to infection. We review the current structural and functional work on this system and argue that intrinsically disordered regions and protein dynamics are central for assembly, exo-protein recognition, and secretion competence of the T2SS. The central role of intrinsic disorder-order transitions in these processes may be a particular feature of type II secretion.

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