The role of Irf6 in tooth epithelial invagination

James Blackburn; Atsushi Ohazama; Katsushige Kawasaki; Yoko Otsuka-Tanaka; Bigang Liu; Kenya Honda; Ryan B. Rountree; Yinling Hu; Maiko Kawasaki; Walter Birchmeier; Ruth Schmidt-Ullrich; Akira Kinoshita; Brian C. Schutte; Nigel L. Hammond; Michael J. Dixon; Paul T. Sharpe

doi:10.1016/j.ydbio.2012.02.009

The role of Irf6 in tooth epithelial invagination

James Blackburn, Atsushi Ohazama^*, Katsushige Kawasaki, Yoko Otsuka-Tanaka, Bigang Liu, Kenya Honda, Ryan B. Rountree, Yinling Hu, Maiko Kawasaki, Walter Birchmeier, Ruth Schmidt-Ullrich, Akira Kinoshita, Brian C. Schutte, Nigel L. Hammond, Michael J. Dixon, Paul T. Sharpe

^*Corresponding author for this work

Centre for Craniofacial & Regenerative Biology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, Irf6 mutant evagination occurs in a NF-κB-independent manner and shows the same molecular changes as those in Ikkα mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos.

Original language	English
Pages (from-to)	61-70
Number of pages	10
Journal	Developmental Biology
Volume	365
Issue number	1
DOIs	https://doi.org/10.1016/j.ydbio.2012.02.009
Publication status	Published - 1 May 2012

Keywords

Epithelium
Ikkα
Incisor
Invagination
Irf6
Tooth development
Wnt

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10.1016/j.ydbio.2012.02.009

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Blackburn, J., Ohazama, A., Kawasaki, K., Otsuka-Tanaka, Y., Liu, B., Honda, K., Rountree, R. B., Hu, Y., Kawasaki, M., Birchmeier, W., Schmidt-Ullrich, R., Kinoshita, A., Schutte, B. C., Hammond, N. L., Dixon, M. J., & Sharpe, P. T. (2012). The role of Irf6 in tooth epithelial invagination. Developmental Biology, 365(1), 61-70. https://doi.org/10.1016/j.ydbio.2012.02.009

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title = "The role of Irf6 in tooth epithelial invagination",

abstract = "Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, Irf6 mutant evagination occurs in a NF-κB-independent manner and shows the same molecular changes as those in Ikkα mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos.",

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AU - Liu, Bigang

AU - Honda, Kenya

AU - Rountree, Ryan B.

AU - Hu, Yinling

AU - Kawasaki, Maiko

AU - Birchmeier, Walter

AU - Schmidt-Ullrich, Ruth

AU - Kinoshita, Akira

AU - Schutte, Brian C.

AU - Hammond, Nigel L.

AU - Dixon, Michael J.

AU - Sharpe, Paul T.

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N2 - Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, Irf6 mutant evagination occurs in a NF-κB-independent manner and shows the same molecular changes as those in Ikkα mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos.

AB - Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikkα has been shown to play a critical role in controlling epithelial growth, since Ikkα mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikkα mutants, Irf6 mutant evagination occurs in a NF-κB-independent manner and shows the same molecular changes as those in Ikkα mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikkα and Irf6 mutant embryos.

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The role of Irf6 in tooth epithelial invagination

Abstract

Keywords

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