The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study

John D. Herrington; Simon Baron-Cohen; Sally J. Wheelwright; Krishna D. Singh; Edward I. Bullmore; Michael Brammer; Steven Williams

doi:10.1016/j.rasd.2006.07.002

The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study

John D. Herrington, Simon Baron-Cohen, Sally J. Wheelwright, Krishna D. Singh, Edward I. Bullmore, Michael Brammer, Steven Williams

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Abstract

Asperger Syndrome (AS), a condition on the autistic spectrum, is characterized by deficits in the ability to use social cues to infer mental state information. Few studies have examined whether these deficits might be understood in terms of differences in visual information processing. The present study employed functional magnetic resonance imaging to examine differences in brain activity among individuals with AS while performing a task that typically leads to the automatic interpretation of human movement. Despite similar behavioural performance, significantly less activity was found for the AS group (relative to a control group) in inferior, middle and superior temporal regions, including the human analogue of MT+/V5. These data suggest that AS is associated with unique patterns of brain activity during the perception of visually presented social cues. (C) 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	14-27
Number of pages	14
Journal	Research In Autism Spectrum Disorders
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.rasd.2006.07.002
Publication status	Published - Jan 2007

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abstract = "Asperger Syndrome (AS), a condition on the autistic spectrum, is characterized by deficits in the ability to use social cues to infer mental state information. Few studies have examined whether these deficits might be understood in terms of differences in visual information processing. The present study employed functional magnetic resonance imaging to examine differences in brain activity among individuals with AS while performing a task that typically leads to the automatic interpretation of human movement. Despite similar behavioural performance, significantly less activity was found for the AS group (relative to a control group) in inferior, middle and superior temporal regions, including the human analogue of MT+/V5. These data suggest that AS is associated with unique patterns of brain activity during the perception of visually presented social cues. (C) 2006 Elsevier Ltd. All rights reserved.",

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AU - Bullmore, Edward I.

AU - Brammer, Michael

AU - Williams, Steven

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AB - Asperger Syndrome (AS), a condition on the autistic spectrum, is characterized by deficits in the ability to use social cues to infer mental state information. Few studies have examined whether these deficits might be understood in terms of differences in visual information processing. The present study employed functional magnetic resonance imaging to examine differences in brain activity among individuals with AS while performing a task that typically leads to the automatic interpretation of human movement. Despite similar behavioural performance, significantly less activity was found for the AS group (relative to a control group) in inferior, middle and superior temporal regions, including the human analogue of MT+/V5. These data suggest that AS is associated with unique patterns of brain activity during the perception of visually presented social cues. (C) 2006 Elsevier Ltd. All rights reserved.

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JO - Research In Autism Spectrum Disorders

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The role of MT+/V5 during biological motion perception in Asperger Syndrome: An fMRI study

Abstract

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