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The role of retinoic acid in establishing the early limb bud

Research output: Contribution to journalReview article

Original languageEnglish
Article number312
JournalBiomolecules
Volume10
Issue number2
DOIs
Publication statusPublished - 13 Feb 2020

King's Authors

Abstract

Retinoic acid (RA) was one of the first molecules in the modern era of experimental embryology to be shown capable of generating profound effects on limb development. In this review, we focus on the earliest events of limb development and specifically on the role of RA in establishing the domain of cells that will go on to form the limb itself. Although there is some consensus on the role of RA during the earliest stages of limb formation, some controversy remains on the mechanism of RA action and the requirement for RA signaling in forming the hindlimb buds.

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