The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

Katherine R. Long; Wieland B. Huttner

doi:10.3389/fncel.2021.804649

The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

Katherine R. Long^*, Wieland B. Huttner

^*Corresponding author for this work

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human neocortex is not yet fully understood. In this review we discuss the role of the ECM in human neocortex development and the different model systems that can be used to investigate this. In particular, we will focus on how the ECM regulates human neural stem and progenitor cell proliferation and differentiation, how the ECM regulates the architecture of the developing human neocortex and the effect of mutations in ECM and ECM-associated genes in neurodevelopmental disorders.

Original language	English
Article number	804649
Journal	Frontiers in cellular neuroscience
Volume	15
Early online date	24 Jan 2022
DOIs	https://doi.org/10.3389/fncel.2021.804649
Publication status	Published - 24 Jan 2022

Keywords

development
extracelluar matrix
human
neocortex
neural progenitor

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abstract = "Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human neocortex is not yet fully understood. In this review we discuss the role of the ECM in human neocortex development and the different model systems that can be used to investigate this. In particular, we will focus on how the ECM regulates human neural stem and progenitor cell proliferation and differentiation, how the ECM regulates the architecture of the developing human neocortex and the effect of mutations in ECM and ECM-associated genes in neurodevelopmental disorders.",

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The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

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Keywords

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