The role of the gut/brain axis in modulating food intake

Amir H. Sam; Rachel C. Troke; Tricia M. Tan; Gavin Bewick

doi:10.1016/j.neuropharm.2011.10.008

The role of the gut/brain axis in modulating food intake

Amir H. Sam, Rachel C. Troke, Tricia M. Tan, Gavin Bewick

Imperial College London

Research output: Contribution to journal › Literature review › peer-review

138 Citations (Scopus)

Abstract

Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity.

Original language	English
Article number	N/A
Pages (from-to)	46-56
Number of pages	11
Journal	Neuropharmacology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/j.neuropharm.2011.10.008
Publication status	Published - Jul 2012

Keywords

Peptide YY (PYY)
Glucagon like peptide-1 (GLP-1)
Oxyntomodulin
Cholecystokinin
Ghrelin
Obesity
GLUCAGON-LIKE PEPTIDE-1
CENTRAL-NERVOUS-SYSTEM
GASTROINTESTINAL SATIETY SIGNALS
HYPOTHALAMIC ARCUATE NUCLEUS
HUMAN PANCREATIC-POLYPEPTIDE
GROWTH-HORMONE-SECRETION
GASTRIC BYPASS-SURGERY
PLASMA GHRELIN LEVELS
SPONTANEOUS MEAL SIZE
DIET-INDUCED OBESITY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuropharm.2011.10.008

Cite this

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title = "The role of the gut/brain axis in modulating food intake",

abstract = "Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity.",

keywords = "Peptide YY (PYY), Glucagon like peptide-1 (GLP-1), Oxyntomodulin, Cholecystokinin, Ghrelin, Obesity, GLUCAGON-LIKE PEPTIDE-1, CENTRAL-NERVOUS-SYSTEM, GASTROINTESTINAL SATIETY SIGNALS, HYPOTHALAMIC ARCUATE NUCLEUS, HUMAN PANCREATIC-POLYPEPTIDE, GROWTH-HORMONE-SECRETION, GASTRIC BYPASS-SURGERY, PLASMA GHRELIN LEVELS, SPONTANEOUS MEAL SIZE, DIET-INDUCED OBESITY",

author = "Sam, {Amir H.} and Troke, {Rachel C.} and Tan, {Tricia M.} and Gavin Bewick",

year = "2012",

month = jul,

doi = "10.1016/j.neuropharm.2011.10.008",

language = "English",

volume = "63",

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journal = "Neuropharmacology",

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T1 - The role of the gut/brain axis in modulating food intake

AU - Sam, Amir H.

AU - Troke, Rachel C.

AU - Tan, Tricia M.

AU - Bewick, Gavin

PY - 2012/7

Y1 - 2012/7

N2 - Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity.

AB - Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity.

KW - Peptide YY (PYY)

KW - Glucagon like peptide-1 (GLP-1)

KW - Oxyntomodulin

KW - Cholecystokinin

KW - Ghrelin

KW - Obesity

KW - GLUCAGON-LIKE PEPTIDE-1

KW - CENTRAL-NERVOUS-SYSTEM

KW - GASTROINTESTINAL SATIETY SIGNALS

KW - HYPOTHALAMIC ARCUATE NUCLEUS

KW - HUMAN PANCREATIC-POLYPEPTIDE

KW - GROWTH-HORMONE-SECRETION

KW - GASTRIC BYPASS-SURGERY

KW - PLASMA GHRELIN LEVELS

KW - SPONTANEOUS MEAL SIZE

KW - DIET-INDUCED OBESITY

U2 - 10.1016/j.neuropharm.2011.10.008

DO - 10.1016/j.neuropharm.2011.10.008

M3 - Literature review

SN - 0028-3908

VL - 63

SP - 46

EP - 56

JO - Neuropharmacology

JF - Neuropharmacology

IS - 1

M1 - N/A

ER -

The role of the gut/brain axis in modulating food intake

Abstract

Keywords

UN SDGs

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