TY - JOUR
T1 - The role of tissue maturity and mechanical state in controlling cell extrusion
AU - Zulueta-Coarasa, Teresa
AU - Rosenblatt, Jody
N1 - Funding Information:
An EMBO Long-Term Fellowship (ALTF 1130-2018) and a Marie Sklodowska-Curie European Union Horizon 2020 research and innovation grant ( 840767 ) funded T.Z.-C. A King’s College start-up grant, Academy of Medical Sciences Professorship (APR2\1007), and a Wellcome Trust Investigator Award (221908/Z/20/Z) funded JR.
Publisher Copyright:
© 2021 The Author(s)
PY - 2022/2
Y1 - 2022/2
N2 - Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whole tissue-, rather than single cell-mechanics in controlling extrusion. Tissue compaction, stiffness, and cell-cell adhesion can impact the efficiency of cell extrusion and mechanisms that drive it, to adapt to different conditions during development or disease.
AB - Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whole tissue-, rather than single cell-mechanics in controlling extrusion. Tissue compaction, stiffness, and cell-cell adhesion can impact the efficiency of cell extrusion and mechanisms that drive it, to adapt to different conditions during development or disease.
UR - http://www.scopus.com/inward/record.url?scp=85115163960&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2021.09.003
DO - 10.1016/j.gde.2021.09.003
M3 - Review article
C2 - 34560388
SN - 0959-437X
VL - 72
SP - 1
EP - 7
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -