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The role of TRP channels in white matter function and ischaemia

Research output: Contribution to journalArticle

Marion Cornillot, Vincenzo Giacco, Nicola B. Hamilton

Original languageEnglish
JournalNeuroscience Letters
Early online date23 Oct 2018
DOIs
Accepted/In press18 Oct 2018
E-pub ahead of print23 Oct 2018

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Abstract

Transient receptor potential (TRP) proteins are a large family of tetrameric non-selective cation channels that are widely expressed in the grey and white matter of the CNS, and are increasingly considered as potential therapeutic targets in brain disorders. Here we briefly review the evidence for TRP channel expression in glial cells and their possible role in both glial cell physiology and stroke. Despite their contribution to important functions, our understanding of the roles of TRP channels in glia is still in its infancy. The evidence reviewed here indicates that further investigation is needed to determine whether TRP channel inhibition can decrease damage or increase repair in stroke and other diseases affecting the white matter.

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