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The role of uterine artery Doppler in predicting adverse pregnancy outcome

Research output: Contribution to journalConference paper

A T Papageorghiou, C K H Yu, K H Nicolaides

Original languageEnglish
Pages (from-to)383 - 396
Number of pages14
JournalBest Practice & Research Clinical Obstetrics & Gynaecology
Volume18
Issue number3
Publication statusPublished - Jun 2004
Event7th International Symposium on Intrauterine Surveillance - London, ENGLAND
Duration: 1 Jan 2004 → …

King's Authors

Abstract

The complications of placental insufficiency, pre-eclampsia and fetal growth restriction (FGR) are major causes of perinatal as well as maternal morbidity and mortality. In normal pregnancy, impedance to flow in the uterine arteries decreases with gestation, and histopathological studies suggest that this is due to trophoblastic invasion of the spiral arteries and their conversion into low-resistance vessels. Failure of trophoblastic invasion is associated with complications of uteroplacental insufficiency. Several Doppler screening studies, both in the second and more recently in the first trimester of pregnancy, have demonstrated an association between increased impedance to flow in the uterine arteries and subsequent development of pre-eclampsia, FGR and perinatal death.

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