The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease

TY - JOUR

T1 - The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease

AU - Benarroch, Rashi

AU - Austin, Jennifer M.

AU - Ahmed, Fahmeda

AU - Isaacson, Rivka L.

PY - 2018/12/18

Y1 - 2018/12/18

N2 - SGTA is a co-chaperone that, in collaboration with the complex of BAG6/UBL4A/TRC35, facilitates the biogenesis and quality control of hydrophobic proteins, protecting them from the aqueous cytosolic environment. This work includes targeting tail-anchored proteins to their resident membranes, sorting of membrane and secretory proteins that mislocalize to the cytoplasm and endoplasmic reticulum-associated degradation of misfolded proteins. Since these functions are all vital for the cell's continued proteostasis, their disruption poses a threat to the cell, with a particular risk of protein aggregation, a phenomenon that underpins many diseases. Although the specific disease implications of machinery involved in quality control of hydrophobic substrates are poorly understood, here we summarize much of the available information on this topic.

AB - SGTA is a co-chaperone that, in collaboration with the complex of BAG6/UBL4A/TRC35, facilitates the biogenesis and quality control of hydrophobic proteins, protecting them from the aqueous cytosolic environment. This work includes targeting tail-anchored proteins to their resident membranes, sorting of membrane and secretory proteins that mislocalize to the cytoplasm and endoplasmic reticulum-associated degradation of misfolded proteins. Since these functions are all vital for the cell's continued proteostasis, their disruption poses a threat to the cell, with a particular risk of protein aggregation, a phenomenon that underpins many diseases. Although the specific disease implications of machinery involved in quality control of hydrophobic substrates are poorly understood, here we summarize much of the available information on this topic.

KW - BAG6

KW - Chaperones

KW - Co-chaperones

KW - Hydrophobic proteins

KW - Proteostasis

KW - Quality control

KW - SGTA

KW - Tail-anchored proteins

KW - TRC35

KW - UBL4A

UR - http://www.scopus.com/inward/record.url?scp=85058502195&partnerID=8YFLogxK

U2 - 10.1016/bs.apcsb.2018.11.002

DO - 10.1016/bs.apcsb.2018.11.002

M3 - Article

AN - SCOPUS:85058502195

SN - 1876-1623

JO - Advances in Protein Chemistry and Structural Biology

JF - Advances in Protein Chemistry and Structural Biology

ER -