The Roles of T-Box Genes in Vertebrate Limb Development

TY - JOUR

T1 - The Roles of T-Box Genes in Vertebrate Limb Development

AU - Sheeba, C. J.

AU - Logan, M. P. O.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Members of the T-box gene family have diverse roles during embryogenesis and many play critical roles in the developing limb. This is exemplified by the fact that, in humans, mutations in T-box genes are associated with several congenital syndromes that include limb defects as part of their characteristic spectrum of abnormalities. T-box genes encode for evolutionary conserved transcription factors that include both transcriptional activators and repressors. The hallmark of T-box gene members is the presence of the eponymous DNA-binding T-box domain. There are 17 mammalian T-box genes, which based on the sequence homology of the T-box domain, are grouped into five subfamilies, namely, . T, . Tbx1, . Tbx2, . Tbx6, and . Tbr1. At least nine T-box genes are expressed during limb development with distinct and dynamic expression patterns. All four members of Tbx2 subfamily (Tbx2, . Tbx3, . Tbx4, . Tbx5) and three members of . Tbx1 (Tbx1, . Tbx15, . Tbx18), . Brachyury (T) and . Eomes (Tbr2) are expressed in the developing limb.

AB - Members of the T-box gene family have diverse roles during embryogenesis and many play critical roles in the developing limb. This is exemplified by the fact that, in humans, mutations in T-box genes are associated with several congenital syndromes that include limb defects as part of their characteristic spectrum of abnormalities. T-box genes encode for evolutionary conserved transcription factors that include both transcriptional activators and repressors. The hallmark of T-box gene members is the presence of the eponymous DNA-binding T-box domain. There are 17 mammalian T-box genes, which based on the sequence homology of the T-box domain, are grouped into five subfamilies, namely, . T, . Tbx1, . Tbx2, . Tbx6, and . Tbr1. At least nine T-box genes are expressed during limb development with distinct and dynamic expression patterns. All four members of Tbx2 subfamily (Tbx2, . Tbx3, . Tbx4, . Tbx5) and three members of . Tbx1 (Tbx1, . Tbx15, . Tbx18), . Brachyury (T) and . Eomes (Tbr2) are expressed in the developing limb.

KW - Apical ectodermal ridge (AER)

KW - Congenital limb abnormalities

KW - FGF signaling

KW - Hox genes

KW - Limb

KW - Limb bud initiation

KW - Limb patterning

KW - Shh signaling

KW - T-box genes

KW - Zone of polarizing activity (ZPA)

UR - http://www.scopus.com/inward/record.url?scp=85002062764&partnerID=8YFLogxK

U2 - 10.1016/bs.ctdb.2016.08.009

DO - 10.1016/bs.ctdb.2016.08.009

M3 - Article

AN - SCOPUS:85002062764

SN - 0070-2153

VL - 122

SP - 355

EP - 381

JO - Current Topics in Developmental Biology

JF - Current Topics in Developmental Biology

ER -