The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia.

Andrea Du Preez; Sophie Lefevre-Arbogast; Vikki Houghton; Chiara De Lucia; Dorrain Y. Low; Catherine Helmer; Catherine Feart; Cécile Delcourt; Cécile Proust-Lima; Merce Pallas; Silvie R.  Ruigrok; Barbara  Altendorfer; Raúl  González-Domínguez; Alex Sanchez-Pla; Mireia Urpi-Sarda; Cristina Andrés-Lacueva; Ludwig Aigner; Paul J. Lucassen; Aniko Korosi; Claudine Manach; Cécilia Samieri; Sandrine Thuret

The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia.

Andrea Du Preez, Sophie Lefevre-Arbogast, Vikki Houghton, Chiara De Lucia, Dorrain Y. Low, Catherine Helmer, Catherine Feart, Cécile Delcourt, Cécile Proust-Lima, Merce Pallas, Silvie R. Ruigrok, Barbara Altendorfer, Raúl González-Domínguez, Alex Sanchez-Pla, Mireia Urpi-Sarda, Cristina Andrés-Lacueva, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Claudine ManachCécilia Samieri, Sandrine Thuret^*

^*Corresponding author for this work

Basic and Clinical Neuroscience

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

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Abstract

Introduction
Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia.

Methods
Using an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12-year period.

Results
Altered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis.

Discussion
Diet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.

Original language	English
Pages (from-to)	654-675
Journal	Alzheimers & Dementia
Volume	18
Issue number	4
Early online date	17 Aug 2021
Publication status	Published - Apr 2022

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The serum metabolome mediates_DUPREEZ_Publishedonline17August2021_GOLD_VoR (CC BY)Final published version, 6.12 MBLicence: CC BY

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Du Preez, A., Lefevre-Arbogast, S., Houghton, V., De Lucia, C., Low, D. Y., Helmer, C., Feart, C., Delcourt, C., Proust-Lima, C., Pallas, M., Ruigrok, S. R., Altendorfer, B., González-Domínguez, R., Sanchez-Pla, A., Urpi-Sarda, M., Andrés-Lacueva, C., Aigner, L., Lucassen, P. J., Korosi, A., ... Thuret, S. (2022). The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimers & Dementia, 18(4), 654-675.

@article{8308fe98e9a7484eaff7effd69781ec4,

title = "The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia.",

abstract = "IntroductionDiet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia.MethodsUsing an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12-year period.ResultsAltered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis.DiscussionDiet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.",

author = "{Du Preez}, Andrea and Sophie Lefevre-Arbogast and Vikki Houghton and {De Lucia}, Chiara and Low, {Dorrain Y.} and Catherine Helmer and Catherine Feart and C{\'e}cile Delcourt and C{\'e}cile Proust-Lima and Merce Pallas and Ruigrok, {Silvie R.} and Barbara Altendorfer and Ra{\'u}l Gonz{\'a}lez-Dom{\'i}nguez and Alex Sanchez-Pla and Mireia Urpi-Sarda and Cristina Andr{\'e}s-Lacueva and Ludwig Aigner and Lucassen, {Paul J.} and Aniko Korosi and Claudine Manach and C{\'e}cilia Samieri and Sandrine Thuret",

year = "2022",

month = apr,

language = "English",

volume = "18",

pages = "654--675",

journal = "Alzheimers & Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "4",

}

Du Preez, A, Lefevre-Arbogast, S, Houghton, V , De Lucia, C, Low, DY, Helmer, C, Feart, C, Delcourt, C, Proust-Lima, C, Pallas, M, Ruigrok, SR, Altendorfer, B, González-Domínguez, R, Sanchez-Pla, A, Urpi-Sarda, M, Andrés-Lacueva, C, Aigner, L, Lucassen, PJ, Korosi, A, Manach, C, Samieri, C & Thuret, S 2022, 'The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia.', Alzheimers & Dementia, vol. 18, no. 4, pp. 654-675.

TY - JOUR

T1 - The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia.

AU - Du Preez, Andrea

AU - Lefevre-Arbogast, Sophie

AU - Houghton, Vikki

AU - De Lucia, Chiara

AU - Low, Dorrain Y.

AU - Helmer, Catherine

AU - Feart, Catherine

AU - Delcourt, Cécile

AU - Proust-Lima, Cécile

AU - Pallas, Merce

AU - Ruigrok, Silvie R.

AU - Altendorfer, Barbara

AU - González-Domínguez, Raúl

AU - Sanchez-Pla, Alex

AU - Urpi-Sarda, Mireia

AU - Andrés-Lacueva, Cristina

AU - Aigner, Ludwig

AU - Lucassen, Paul J.

AU - Korosi, Aniko

AU - Manach, Claudine

AU - Samieri, Cécilia

AU - Thuret, Sandrine

PY - 2022/4

Y1 - 2022/4

N2 - IntroductionDiet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia.MethodsUsing an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12-year period.ResultsAltered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis.DiscussionDiet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.

AB - IntroductionDiet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia.MethodsUsing an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12-year period.ResultsAltered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis.DiscussionDiet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.

M3 - Article

SN - 1552-5260

VL - 18

SP - 654

EP - 675

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

IS - 4

ER -

The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia.

Abstract

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