The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo

Laura Cabana; Maxime Bourgognon; Julie T.-W Wang; Andrea Protti; Rebecca Klippstein; Rafael T. M. de Rosales; Ajay M. Shah; Josep Fontcuberta; Ester Tobías-Rossell; Jane K. Sosabowski; Khuloud T. Al-Jamal; Gerard Tobias

doi:10.1002/smll.201502721

The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo

Laura Cabana, Maxime Bourgognon, Julie T.-W Wang, Andrea Protti, Rebecca Klippstein, Rafael T. M. de Rosales, Ajay M. Shah, Josep Fontcuberta, Ester Tobías-Rossell, Jane K. Sosabowski, Khuloud T. Al-Jamal, Gerard Tobias

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Abstract

Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.

Original language	English
Journal	Small
DOIs	https://doi.org/10.1002/smll.201502721
Publication status	E-pub ahead of print - 15 Apr 2016

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The Shortening of MWNT-SPION Hybrids_CABANA First online 15Apr2016 GOLD FPVFinal published version, 1.75 MBLicence: CC BY

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Cabana, L., Bourgognon, M., Wang, J. T. .-W., Protti, A., Klippstein, R., de Rosales, R. T. M., Shah, A. M., Fontcuberta, J., Tobías-Rossell, E., Sosabowski, J. K., Al-Jamal, K. T., & Tobias, G. (2016). The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo. Small. Advance online publication. https://doi.org/10.1002/smll.201502721

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title = "The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo",

abstract = "Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.",

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AU - Cabana, Laura

AU - Bourgognon, Maxime

AU - Wang, Julie T.-W

AU - Protti, Andrea

AU - Klippstein, Rebecca

AU - de Rosales, Rafael T. M.

AU - Shah, Ajay M.

AU - Fontcuberta, Josep

AU - Tobías-Rossell, Ester

AU - Sosabowski, Jane K.

AU - Al-Jamal, Khuloud T.

AU - Tobias, Gerard

PY - 2016/4/15

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N2 - Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.

AB - Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.

U2 - 10.1002/smll.201502721

DO - 10.1002/smll.201502721

M3 - Article

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SN - 1613-6810

JO - Small

JF - Small

ER -

The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo

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