TY - JOUR
T1 - The sleep-circadian interface
T2 - A window into mental disorders
AU - Meyer, Nicholas
AU - Lok, Renske
AU - Schmidt, Christina
AU - Kyle, Simon D
AU - McClung, Colleen A
AU - Cajochen, Christian
AU - Scheer, Frank A J L
AU - Jones, Matthew W
AU - Chellappa, Sarah L
N1 - Publisher Copyright:
© 2024 the Author(s). Published by PNAS.
PY - 2024/2/27
Y1 - 2024/2/27
N2 - Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances can alleviate psychopathology. Conversely, psychiatric symptoms can reciprocally exacerbate poor sleep and disrupt clock-controlled processes. Despite progress in elucidating underlying mechanisms, a cohesive approach that integrates the dynamic interactions between psychiatric disorder with both sleep and circadian processes is lacking. This review synthesizes recent evidence for sleep-circadian dysfunction as a transdiagnostic contributor to a range of psychiatric disorders, with an emphasis on biological mechanisms. We highlight observations from adolescent and young adults, who are at greatest risk of developing mental disorders, and for whom early detection and intervention promise the greatest benefit. In particular, we aim to a) integrate sleep and circadian factors implicated in the pathophysiology and treatment of mood, anxiety, and psychosis spectrum disorders, with a transdiagnostic perspective; b) highlight the need to reframe existing knowledge and adopt an integrated approach which recognizes the interaction between sleep and circadian factors; and c) identify important gaps and opportunities for further research.
AB - Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances can alleviate psychopathology. Conversely, psychiatric symptoms can reciprocally exacerbate poor sleep and disrupt clock-controlled processes. Despite progress in elucidating underlying mechanisms, a cohesive approach that integrates the dynamic interactions between psychiatric disorder with both sleep and circadian processes is lacking. This review synthesizes recent evidence for sleep-circadian dysfunction as a transdiagnostic contributor to a range of psychiatric disorders, with an emphasis on biological mechanisms. We highlight observations from adolescent and young adults, who are at greatest risk of developing mental disorders, and for whom early detection and intervention promise the greatest benefit. In particular, we aim to a) integrate sleep and circadian factors implicated in the pathophysiology and treatment of mood, anxiety, and psychosis spectrum disorders, with a transdiagnostic perspective; b) highlight the need to reframe existing knowledge and adopt an integrated approach which recognizes the interaction between sleep and circadian factors; and c) identify important gaps and opportunities for further research.
KW - Young Adult
KW - Adolescent
KW - Humans
KW - Mental Disorders/etiology
KW - Sleep/physiology
KW - Circadian Rhythm/physiology
KW - Sleep Wake Disorders
KW - Mental Health
KW - Mood Disorders
UR - http://www.scopus.com/inward/record.url?scp=85185855480&partnerID=8YFLogxK
U2 - 10.1073/pnas.2214756121
DO - 10.1073/pnas.2214756121
M3 - Review article
C2 - 38394243
SN - 0027-8424
VL - 121
SP - e2214756121
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 9
M1 - e2214756121
ER -