Abstract
Wavefronts from virtual-electrodes, in response to field-stimulation, are thought to be the main mechanism behind the success of low-energy defibrillation protocols. In this work the concept of the strength-interval curve, usually associated with uni-polar stimulation, is extended to field-stimulation for specific geometrical features - in this case blood-vessels (with realistic fibre architecture and vessel walls) - as the coronary vasculature is known to be an important source of virtual-electrode induced wavefronts. It is shown that, because there is no concept of anodal or cathodal responses in field-stimulation, there is only one strength-interval curve for blood-vessels, and the usual phenomena of make and break excitations are observed for different diastolic intervals. Break excitations occur because regions of de and hyper-polarization are in close proximity due to the resultant virtual-electrode pattern, and they allow excitation at lower field-strengths while the surrounding tissue is relatively refractory. This effect may be important for optimizing low-energy defibrillation protocols.
| Original language | English |
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| Title of host publication | Computing in Cardiology Conference, CinC 2016 |
| Publisher | IEEE Computer Society |
| Pages | 173-176 |
| Number of pages | 4 |
| Volume | 43 |
| ISBN (Electronic) | 9781509008964 |
| Publication status | Published - 1 Mar 2017 |
| Event | 43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada Duration: 11 Sept 2016 → 14 Sept 2016 |
Conference
| Conference | 43rd Computing in Cardiology Conference, CinC 2016 |
|---|---|
| Country/Territory | Canada |
| City | Vancouver |
| Period | 11/09/2016 → 14/09/2016 |