The strength-interval curve for blood vessels

Adam Connolly*, Martin J. Bishop

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingOther chapter contributionpeer-review


Wavefronts from virtual-electrodes, in response to field-stimulation, are thought to be the main mechanism behind the success of low-energy defibrillation protocols. In this work the concept of the strength-interval curve, usually associated with uni-polar stimulation, is extended to field-stimulation for specific geometrical features - in this case blood-vessels (with realistic fibre architecture and vessel walls) - as the coronary vasculature is known to be an important source of virtual-electrode induced wavefronts. It is shown that, because there is no concept of anodal or cathodal responses in field-stimulation, there is only one strength-interval curve for blood-vessels, and the usual phenomena of make and break excitations are observed for different diastolic intervals. Break excitations occur because regions of de and hyper-polarization are in close proximity due to the resultant virtual-electrode pattern, and they allow excitation at lower field-strengths while the surrounding tissue is relatively refractory. This effect may be important for optimizing low-energy defibrillation protocols.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2016
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781509008964
Publication statusPublished - 1 Mar 2017
Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
Duration: 11 Sept 201614 Sept 2016


Conference43rd Computing in Cardiology Conference, CinC 2016


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