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The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle

Research output: Contribution to journalReview article

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The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle. / Lavorato, Manuela; Formenti, Federico; Franzini-Armstrong, Clara.

In: Experimental Physiology, Vol. 105, No. 4, 01.04.2020, p. 606-612.

Research output: Contribution to journalReview article

Harvard

Lavorato, M, Formenti, F & Franzini-Armstrong, C 2020, 'The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle', Experimental Physiology, vol. 105, no. 4, pp. 606-612. https://doi.org/10.1113/EP087503

APA

Lavorato, M., Formenti, F., & Franzini-Armstrong, C. (2020). The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle. Experimental Physiology, 105(4), 606-612. https://doi.org/10.1113/EP087503

Vancouver

Lavorato M, Formenti F, Franzini-Armstrong C. The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle. Experimental Physiology. 2020 Apr 1;105(4):606-612. https://doi.org/10.1113/EP087503

Author

Lavorato, Manuela ; Formenti, Federico ; Franzini-Armstrong, Clara. / The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle. In: Experimental Physiology. 2020 ; Vol. 105, No. 4. pp. 606-612.

Bibtex Download

@article{1cd272899a9e4495bf12443cd7ab1380,
title = "The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle",
abstract = "This review focuses on recent discoveries in skeletal and cardiac muscles indicating that mitochondria behave as an interactive cohort with inter‐organelle communication and specific reactions to stress signals. Our new finding is that intermitochondrial communications in cardiac and skeletal muscles rely on two distinct methods. In cardiac muscle, mitochondria are discrete entities and are fairly well immobilized in a structural context. The organelles have developed a unique method of communication, via nanotunnels, which allow temporary connection from one mitochondrion to another over distances of up to several micrometres, without overall movement of the individual organelles and loss of their identity. Skeletal muscle mitochondria, in contrast, are dynamic. Through fusion, fission and elongation, they form connections that include constrictions and connecting ducts (distinct from nanotunnels) and lose individual identity in the formation of extensive networks. Connecting elements in skeletal muscle are distinct from nanotunnels in cardiac muscle.",
keywords = "mitochondria, cardiac muscle, skeletal muscle, nanotunnel, ultrastructural imaging, electron microscopy",
author = "Manuela Lavorato and Federico Formenti and Clara Franzini-Armstrong",
year = "2020",
month = apr,
day = "1",
doi = "10.1113/EP087503",
language = "English",
volume = "105",
pages = "606--612",
journal = "Experimental Physiology",
issn = "0958-0670",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle

AU - Lavorato, Manuela

AU - Formenti, Federico

AU - Franzini-Armstrong, Clara

PY - 2020/4/1

Y1 - 2020/4/1

N2 - This review focuses on recent discoveries in skeletal and cardiac muscles indicating that mitochondria behave as an interactive cohort with inter‐organelle communication and specific reactions to stress signals. Our new finding is that intermitochondrial communications in cardiac and skeletal muscles rely on two distinct methods. In cardiac muscle, mitochondria are discrete entities and are fairly well immobilized in a structural context. The organelles have developed a unique method of communication, via nanotunnels, which allow temporary connection from one mitochondrion to another over distances of up to several micrometres, without overall movement of the individual organelles and loss of their identity. Skeletal muscle mitochondria, in contrast, are dynamic. Through fusion, fission and elongation, they form connections that include constrictions and connecting ducts (distinct from nanotunnels) and lose individual identity in the formation of extensive networks. Connecting elements in skeletal muscle are distinct from nanotunnels in cardiac muscle.

AB - This review focuses on recent discoveries in skeletal and cardiac muscles indicating that mitochondria behave as an interactive cohort with inter‐organelle communication and specific reactions to stress signals. Our new finding is that intermitochondrial communications in cardiac and skeletal muscles rely on two distinct methods. In cardiac muscle, mitochondria are discrete entities and are fairly well immobilized in a structural context. The organelles have developed a unique method of communication, via nanotunnels, which allow temporary connection from one mitochondrion to another over distances of up to several micrometres, without overall movement of the individual organelles and loss of their identity. Skeletal muscle mitochondria, in contrast, are dynamic. Through fusion, fission and elongation, they form connections that include constrictions and connecting ducts (distinct from nanotunnels) and lose individual identity in the formation of extensive networks. Connecting elements in skeletal muscle are distinct from nanotunnels in cardiac muscle.

KW - mitochondria

KW - cardiac muscle

KW - skeletal muscle

KW - nanotunnel

KW - ultrastructural imaging

KW - electron microscopy

UR - http://www.scopus.com/inward/record.url?scp=85082655292&partnerID=8YFLogxK

U2 - 10.1113/EP087503

DO - 10.1113/EP087503

M3 - Review article

VL - 105

SP - 606

EP - 612

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 4

ER -

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