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THE SUBTYPING OF SCHIZOPHRENIA IN MEN AND WOMEN - A LATENT CLASS ANALYSIS

Research output: Contribution to journalArticle

D J CASTLE, P C SHAM, S WESSELY, R M MURRAY

Original languageEnglish
Pages (from-to)41-51
Number of pages11
JournalPsychological Medicine
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 1994

King's Authors

Abstract

Latent class analysis on an epidemiologically based series of 447 first contact patients with a broad diagnosis of schizophrenia revealed evidence for two subtypes: a 'neurodevelopmental' type characterized by early onset, poor pre-morbid social adjustment, restricted affect and a male: female ratio of 7: 3; and a 'paranoid' type characterized by later onset, persecutory delusions and an almost equal sex ratio. A third 'schizoaffective' subtype, whose existence was less clear cut, was almost entirely confined to females and characterized by dysphoria and persecutory delusions, and had negligible familial risk of schizophrenia. The aetiological, biological and clinical significance of this typology remains to be tested.

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