The synthesis and properties of mitochondrial targeted iron chelators

Agostino Cilibrizzi; Charareh Pourzand; Vincenzo Abbate; Olivier Reelfs; Laura Versari; Giuseppe Floresta; Robert Hider

doi:10.1007/s10534-022-00383-8

The synthesis and properties of mitochondrial targeted iron chelators

Agostino Cilibrizzi, Charareh Pourzand, Vincenzo Abbate, Olivier Reelfs, Laura Versari, Giuseppe Floresta, Robert Hider^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.

Original language	English
Journal	Biometals
DOIs	https://doi.org/10.1007/s10534-022-00383-8
Publication status	Accepted/In press - 2022

Keywords

Chelator synthesis
Iron chelation
Iron-probe
Mitochondria

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title = "The synthesis and properties of mitochondrial targeted iron chelators",

abstract = "Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.",

keywords = "Chelator synthesis, Iron chelation, Iron-probe, Mitochondria",

author = "Agostino Cilibrizzi and Charareh Pourzand and Vincenzo Abbate and Olivier Reelfs and Laura Versari and Giuseppe Floresta and Robert Hider",

note = "Funding Information: We wish to thank the BBSRC (Grant No. BB/J005223/1) and Parkinson{\textquoteright}s UK (Grant No. K-1603) for the generous support of this work. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

doi = "10.1007/s10534-022-00383-8",

language = "English",

journal = "Biometals",

issn = "0966-0844",

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T1 - The synthesis and properties of mitochondrial targeted iron chelators

AU - Cilibrizzi, Agostino

AU - Pourzand, Charareh

AU - Abbate, Vincenzo

AU - Reelfs, Olivier

AU - Versari, Laura

AU - Floresta, Giuseppe

AU - Hider, Robert

PY - 2022

Y1 - 2022

N2 - Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.

AB - Iron levels in mitochondria are critically important for the normal functioning of the organelle. Abnormal levels of iron and the associated formation of toxic oxygen radicals have been linked to a wide range of diseases and consequently it is important to be able to both monitor and control levels of the mitochondrial labile iron pool. To this end a series of iron chelators which are targeted to mitochondria have been designed. This overview describes the synthesis of some of these molecules and their application in monitoring mitochondrial labile iron pools and in selectively removing excess iron from mitochondria.

KW - Chelator synthesis

KW - Iron chelation

KW - Iron-probe

KW - Mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85127617227&partnerID=8YFLogxK

U2 - 10.1007/s10534-022-00383-8

DO - 10.1007/s10534-022-00383-8

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AN - SCOPUS:85127617227

SN - 0966-0844

JO - Biometals

JF - Biometals

ER -

The synthesis and properties of mitochondrial targeted iron chelators

Abstract

Keywords

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