Abstract
As part of our program to develop PET tracers for the 5-HT reuptake site, venlafaxine, a non-classical, fast-acting antidepressant, was selected as a candidate for labelling with C-11 for in vivo evaluation. [O-methyl-C-11]venlafaxine was produced by the alkylation of O-desmethyl venlafaxine with [C-11]methyl iodide followed by HPLC purification and formulation. Radiochemically pure [O-methyl-C-11]venlafaxine was obtained in a 30 +/- 5% decay corrected radiochemical yield and a specific activity > 50 GBq/mu mol (1.4 Ci/mu mol) at the end of synthesis. For a typical production starting with 46 GBq (1.3 Ci) [C-11]CO2, 5.2 GBq (140 mCi) [O-methyl-C-11]venlafaxine was obtained as a sterile, formulated solution in a synthesis time of 30 min (counted from EOB).
| Original language | English |
|---|---|
| Pages (from-to) | 89-95 |
| Number of pages | 7 |
| Journal | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS |
| Volume | 39 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1997 |