The Th1 life cycle: molecular control of IFN-gamma to IL-10 switching

Research output: Contribution to journalLiterature reviewpeer-review

202 Citations (Scopus)

Abstract

Control of IFN-gamma-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces "intrinsic" IL-10 expression in cells also expressing IFN-gamma, during Th1 lineage differentiation. Targeting this Th1 cell IFN-gamma to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-gamma versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell costimulatory molecule CD46, and also discussed are challenges and controversies in the field.
Original languageEnglish
Pages (from-to)278 - 286
Number of pages9
JournalTRENDS IN IMMUNOLOGY
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 2011

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