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The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study

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The Topography of Striatal Dopamine and Symptoms in Psychosis : An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study. / McCutcheon, Robert A.; Jauhar, Sameer; Pepper, Fiona; Nour, Matthew M.; Rogdaki, Maria; Veronese, Mattia; Turkheimer, Federico E.; Egerton, Alice; McGuire, Philip; Mehta, Mitul M.; Howes, Oliver D.

In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 23.04.2020.

Research output: Contribution to journalArticle

Harvard

McCutcheon, RA, Jauhar, S, Pepper, F, Nour, MM, Rogdaki, M, Veronese, M, Turkheimer, FE, Egerton, A, McGuire, P, Mehta, MM & Howes, OD 2020, 'The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https://doi.org/10.1016/j.bpsc.2020.04.004

APA

McCutcheon, R. A., Jauhar, S., Pepper, F., Nour, M. M., Rogdaki, M., Veronese, M., Turkheimer, F. E., Egerton, A., McGuire, P., Mehta, M. M., & Howes, O. D. (2020). The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https://doi.org/10.1016/j.bpsc.2020.04.004

Vancouver

McCutcheon RA, Jauhar S, Pepper F, Nour MM, Rogdaki M, Veronese M et al. The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2020 Apr 23. https://doi.org/10.1016/j.bpsc.2020.04.004

Author

McCutcheon, Robert A. ; Jauhar, Sameer ; Pepper, Fiona ; Nour, Matthew M. ; Rogdaki, Maria ; Veronese, Mattia ; Turkheimer, Federico E. ; Egerton, Alice ; McGuire, Philip ; Mehta, Mitul M. ; Howes, Oliver D. / The Topography of Striatal Dopamine and Symptoms in Psychosis : An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study. In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2020.

Bibtex Download

@article{03cc72762fee42839633c999ad219573,
title = "The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study",
abstract = "Background: Striatal dopamine dysfunction is thought to underlie symptoms in psychosis, yet it remains unclear how a single neurotransmitter could cause the diverse presentations that are observed clinically. One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction occurs. Positron emission tomography allows for the quantification of dopamine function across the striatum. In the current study, we used a novel method to investigate the relationship between spatial variability in dopamine synthesis capacity and psychotic symptoms. Methods: We used a multimodal imaging approach combining 18F-DOPA positron emission tomography and resting-state magnetic resonance imaging in 29 patients with first-episode psychosis and 21 healthy control subjects. In each participant, resting-state functional connectivity maps were used to quantify the functional connectivity of each striatal voxel to well-established cortical networks. Network-specific striatal dopamine synthesis capacity (Kicer) was then calculated for the resulting connectivity-defined parcellations. Results: The connectivity-defined parcellations generated Kicer values with equivalent reliability, and significantly greater orthogonality compared with standard anatomical parcellation methods. As a result, dopamine-symptom associations were significantly different from one another for different subdivisions, whereas no unique subdivision relationships were found when using an anatomical parcellation. In particular, dopamine function within striatal areas connected to the default mode network was strongly associated with negative symptoms (p < .001). Conclusions: These findings suggest that individual differences in the topography of dopamine dysfunction within the striatum contribute to shaping psychotic symptomatology. Further validation of the novel approach in future studies is necessary.",
keywords = "Functional connectivity, Negative symptoms, Positive symptoms, Resting state, Schizophrenia, Striatum",
author = "McCutcheon, {Robert A.} and Sameer Jauhar and Fiona Pepper and Nour, {Matthew M.} and Maria Rogdaki and Mattia Veronese and Turkheimer, {Federico E.} and Alice Egerton and Philip McGuire and Mehta, {Mitul M.} and Howes, {Oliver D.}",
year = "2020",
month = apr,
day = "23",
doi = "10.1016/j.bpsc.2020.04.004",
language = "English",
journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
issn = "2451-9022",
publisher = "Elsevier Inc.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The Topography of Striatal Dopamine and Symptoms in Psychosis

T2 - An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study

AU - McCutcheon, Robert A.

AU - Jauhar, Sameer

AU - Pepper, Fiona

AU - Nour, Matthew M.

AU - Rogdaki, Maria

AU - Veronese, Mattia

AU - Turkheimer, Federico E.

AU - Egerton, Alice

AU - McGuire, Philip

AU - Mehta, Mitul M.

AU - Howes, Oliver D.

PY - 2020/4/23

Y1 - 2020/4/23

N2 - Background: Striatal dopamine dysfunction is thought to underlie symptoms in psychosis, yet it remains unclear how a single neurotransmitter could cause the diverse presentations that are observed clinically. One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction occurs. Positron emission tomography allows for the quantification of dopamine function across the striatum. In the current study, we used a novel method to investigate the relationship between spatial variability in dopamine synthesis capacity and psychotic symptoms. Methods: We used a multimodal imaging approach combining 18F-DOPA positron emission tomography and resting-state magnetic resonance imaging in 29 patients with first-episode psychosis and 21 healthy control subjects. In each participant, resting-state functional connectivity maps were used to quantify the functional connectivity of each striatal voxel to well-established cortical networks. Network-specific striatal dopamine synthesis capacity (Kicer) was then calculated for the resulting connectivity-defined parcellations. Results: The connectivity-defined parcellations generated Kicer values with equivalent reliability, and significantly greater orthogonality compared with standard anatomical parcellation methods. As a result, dopamine-symptom associations were significantly different from one another for different subdivisions, whereas no unique subdivision relationships were found when using an anatomical parcellation. In particular, dopamine function within striatal areas connected to the default mode network was strongly associated with negative symptoms (p < .001). Conclusions: These findings suggest that individual differences in the topography of dopamine dysfunction within the striatum contribute to shaping psychotic symptomatology. Further validation of the novel approach in future studies is necessary.

AB - Background: Striatal dopamine dysfunction is thought to underlie symptoms in psychosis, yet it remains unclear how a single neurotransmitter could cause the diverse presentations that are observed clinically. One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction occurs. Positron emission tomography allows for the quantification of dopamine function across the striatum. In the current study, we used a novel method to investigate the relationship between spatial variability in dopamine synthesis capacity and psychotic symptoms. Methods: We used a multimodal imaging approach combining 18F-DOPA positron emission tomography and resting-state magnetic resonance imaging in 29 patients with first-episode psychosis and 21 healthy control subjects. In each participant, resting-state functional connectivity maps were used to quantify the functional connectivity of each striatal voxel to well-established cortical networks. Network-specific striatal dopamine synthesis capacity (Kicer) was then calculated for the resulting connectivity-defined parcellations. Results: The connectivity-defined parcellations generated Kicer values with equivalent reliability, and significantly greater orthogonality compared with standard anatomical parcellation methods. As a result, dopamine-symptom associations were significantly different from one another for different subdivisions, whereas no unique subdivision relationships were found when using an anatomical parcellation. In particular, dopamine function within striatal areas connected to the default mode network was strongly associated with negative symptoms (p < .001). Conclusions: These findings suggest that individual differences in the topography of dopamine dysfunction within the striatum contribute to shaping psychotic symptomatology. Further validation of the novel approach in future studies is necessary.

KW - Functional connectivity

KW - Negative symptoms

KW - Positive symptoms

KW - Resting state

KW - Schizophrenia

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=85087693579&partnerID=8YFLogxK

U2 - 10.1016/j.bpsc.2020.04.004

DO - 10.1016/j.bpsc.2020.04.004

M3 - Article

C2 - 32653578

AN - SCOPUS:85087693579

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

SN - 2451-9022

ER -

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