Abstract
The question of whether a functional variant in the promoter of the serotonin transporter gene (5-HTTLPR) influences response to adversity and/or antidepressants has generated great interest and controversy. A review of the literature suggests that the issue is complicated by differences in methodology and sample ethnicity. When these confounders are accounted for, there probably is a real, if small, effect of 5-HTTLPR on response to both serotonin reuptake inhibitors and environmental adversity.
| Original language | English |
|---|---|
| Pages (from-to) | 424 - 427 |
| Number of pages | 4 |
| Journal | British Journal of Psychiatry |
| Volume | 198 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |