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The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Research output: Contribution to journalArticle

Sunil K Verma, Trivadi S Ganesan, Uday Kishore, Peter J Parker

Original languageEnglish
Pages (from-to)237-249
Number of pages13
JournalProtein & cell
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2011

King's Authors

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

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