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The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

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The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. / Verma, Sunil K; Ganesan, Trivadi S; Kishore, Uday; Parker, Peter J.

In: Protein & cell, Vol. 2, No. 3, 03.2011, p. 237-249.

Research output: Contribution to journalArticle

Harvard

Verma, SK, Ganesan, TS, Kishore, U & Parker, PJ 2011, 'The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A', Protein & cell, vol. 2, no. 3, pp. 237-249. https://doi.org/10.1007/s13238-011-1028-z

APA

Verma, S. K., Ganesan, T. S., Kishore, U., & Parker, P. J. (2011). The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. Protein & cell, 2(3), 237-249. https://doi.org/10.1007/s13238-011-1028-z

Vancouver

Verma SK, Ganesan TS, Kishore U, Parker PJ. The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. Protein & cell. 2011 Mar;2(3):237-249. https://doi.org/10.1007/s13238-011-1028-z

Author

Verma, Sunil K ; Ganesan, Trivadi S ; Kishore, Uday ; Parker, Peter J. / The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A. In: Protein & cell. 2011 ; Vol. 2, No. 3. pp. 237-249.

Bibtex Download

@article{5e343cac484045e3b9f38aac48f6a738,
title = "The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A",
abstract = "Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.",
author = "Verma, {Sunil K} and Ganesan, {Trivadi S} and Uday Kishore and Parker, {Peter J}",
year = "2011",
month = "3",
doi = "10.1007/s13238-011-1028-z",
language = "English",
volume = "2",
pages = "237--249",
journal = "Protein & cell",
issn = "1674-800X",
publisher = "Springer-Verlag GmbH and Co. KG",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

AU - Verma, Sunil K

AU - Ganesan, Trivadi S

AU - Kishore, Uday

AU - Parker, Peter J

PY - 2011/3

Y1 - 2011/3

N2 - Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

AB - Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

U2 - 10.1007/s13238-011-1028-z

DO - 10.1007/s13238-011-1028-z

M3 - Article

C2 - 21468893

VL - 2

SP - 237

EP - 249

JO - Protein & cell

JF - Protein & cell

SN - 1674-800X

IS - 3

ER -

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