The use of animal models in diabetes research

TY - JOUR

T1 - The use of animal models in diabetes research

AU - King, Aileen J. F.

PY - 2012/6

Y1 - 2012/6

N2 - Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes. Type 1 diabetes is due to an autoimmune destruction of the insulin-producing pancreatic beta cells, and type 2 diabetes is caused by insulin resistance coupled by a failure of the beta cell to compensate. Animal models for type 1 diabetes range from animals with spontaneously developing autoimmune diabetes to chemical ablation of the pancreatic beta cells. Type 2 diabetes is modelled in both obese and non-obese animal models with varying degrees of insulin resistance and beta cell failure. This review outlines some of the models currently used in diabetes research. In addition, the use of transgenic and knock-out mouse models is discussed. Ideally, more than one animal model should be used to represent the diversity seen in human diabetic patients. LINKED ARTICLES Animal Models This paper is the latest in a series of publications on the use of animal models in pharmacology research. Readers might be interested in the previous papers. Robinson V (2009). . Holmes AM, Rudd JA, Tattersall FD, Aziz Q, Andrews PLR (2009). . Giacomotto J and Segalat L (2010). McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL (2010). . Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010). . Emerson M (2010). . Berge O-G (2011). . Vickers SP, Jackson HC and Cheetham SC (2011). . Percie du Sert N, Holmes AM, Wallis R, Andrews PLR (2012). . The complete series including future publications, as they occur, can be found at .

AB - Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes. Type 1 diabetes is due to an autoimmune destruction of the insulin-producing pancreatic beta cells, and type 2 diabetes is caused by insulin resistance coupled by a failure of the beta cell to compensate. Animal models for type 1 diabetes range from animals with spontaneously developing autoimmune diabetes to chemical ablation of the pancreatic beta cells. Type 2 diabetes is modelled in both obese and non-obese animal models with varying degrees of insulin resistance and beta cell failure. This review outlines some of the models currently used in diabetes research. In addition, the use of transgenic and knock-out mouse models is discussed. Ideally, more than one animal model should be used to represent the diversity seen in human diabetic patients. LINKED ARTICLES Animal Models This paper is the latest in a series of publications on the use of animal models in pharmacology research. Readers might be interested in the previous papers. Robinson V (2009). . Holmes AM, Rudd JA, Tattersall FD, Aziz Q, Andrews PLR (2009). . Giacomotto J and Segalat L (2010). McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, Wainwright CL (2010). . Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010). . Emerson M (2010). . Berge O-G (2011). . Vickers SP, Jackson HC and Cheetham SC (2011). . Percie du Sert N, Holmes AM, Wallis R, Andrews PLR (2012). . The complete series including future publications, as they occur, can be found at .

KW - type 1 diabetes

KW - type 2 diabetes

KW - animal models

KW - LOW-DOSE STREPTOZOTOCIN

KW - BETA-CELL MASS

KW - IMPROVES GLYCEMIC CONTROL

KW - GOTO-KAKIZAKI RATS

KW - ENDOPLASMIC-RETICULUM STRESS

KW - INSULIN-RESISTANCE

KW - PANCREATIC-ISLETS

KW - MOUSE MODEL

KW - GLUCOSE-TOLERANCE

KW - PSAMMOMYS-OBESUS

U2 - 10.1111/j.1476-5381.2012.01911.x

DO - 10.1111/j.1476-5381.2012.01911.x

M3 - Literature review

SN - 0007-1188

VL - 166

SP - 877

EP - 894

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 3

ER -