The use of CXB recombinant inbred mice to detect quantitative trait loci in behavior

TY - JOUR

T1 - The use of CXB recombinant inbred mice to detect quantitative trait loci in behavior

AU - Neiderhiser, J M

AU - Plomin, R

AU - McClearn, G E

PY - 1992/9

Y1 - 1992/9

N2 - Although recombinant inbred (RI) series of mice have been developed to identify and map single-gene characteristics, they can also be used to identify quantitative trait loci (QTL) that account for small amounts of variance in quantitative traits such as behavior. We applied an RI QTL approach to the analysis of published behavioral data from seven studies that used the CXB RI series of mice. Nearly all of the behaviors showed strain distribution patterns indicative of multiple-gene rather than single-gene influence. Although the CXB series is limited to seven RI strains, RI QTL association analysis suggests QTL candidate markers for several behaviors, including avoidance and exploration.

AB - Although recombinant inbred (RI) series of mice have been developed to identify and map single-gene characteristics, they can also be used to identify quantitative trait loci (QTL) that account for small amounts of variance in quantitative traits such as behavior. We applied an RI QTL approach to the analysis of published behavioral data from seven studies that used the CXB RI series of mice. Nearly all of the behaviors showed strain distribution patterns indicative of multiple-gene rather than single-gene influence. Although the CXB series is limited to seven RI strains, RI QTL association analysis suggests QTL candidate markers for several behaviors, including avoidance and exploration.

U2 - 10.1016/0031-9384(92)90328-Y

DO - 10.1016/0031-9384(92)90328-Y

M3 - Article

C2 - 1409902

SN - 0031-9384

VL - 52

SP - 429

EP - 439

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 3

ER -