The use of mice in diabetes research: The impact of physiological characteristics, choice of model and husbandry practices

Lydia F. Daniels Gatward, Matilda R. Kennard, Lorna I.F. Smith, Aileen J.F. King*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of health complications and an overall increased risk of mortality. Mouse models are vital in understanding the pathogenesis of this disease and its complications, as well as for developing new diabetes therapeutics. However, for experimental questions to be suitably tested, it is critical that factors inherent to the animal model are considered, as these can have profound impacts on experimental outcome, data reproducibility and robustness. In this review, we discuss key considerations relating to model choice, physiological characteristics (such as age, sex and genetic background) and husbandry practices and explore the impact of these on common experimental readouts used in preclinical diabetes research.

Original languageEnglish
Article numbere14711
JournalDiabetic Medicine
Volume38
Issue number12
Early online date6 Oct 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • breeding
  • diabetes
  • husbandry
  • mouse models
  • physiological characteristics

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