The use of microbeams to investigate radiation damage in living cells

TY - JOUR

T1 - The use of microbeams to investigate radiation damage in living cells

AU - Folkard, Melvyn

AU - Prise, Kevin M.

AU - Grime, Geoff

AU - Kirkby, Karen

AU - Vojnovic, Boris

PY - 2009/3

Y1 - 2009/3

N2 - The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).

AB - The micro-irradiation technique continues to be highly relevant to a number of radiobiological studies in vitro. In particular, studies of the bystander effect show that direct damage to cells is not the only trigger for radiation-induced effects, but that unirradiated cells can also respond to signals from irradiated neighbours. Furthermore, the bystander response can be initiated even when no energy is deposited in the genomic DNA of the irradiated cell (i.e. by targeting just the cytoplasm).

KW - Microbeam

KW - Nanobeam

KW - Non-targeted effects

KW - Bystander effect

KW - Radiation risk

KW - CHARGED-PARTICLE MICROBEAM

KW - IONIZING-RADIATION

KW - IRRADIATION

KW - SYSTEM

KW - ACCURACY

KW - RISKS

U2 - 10.1016/j.apradiso.2008.06.015

DO - 10.1016/j.apradiso.2008.06.015

M3 - Article

SN - 0969-8043

VL - 67

SP - 436

EP - 439

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 3

M1 - N/A

ER -