TY - JOUR
T1 - The use of neurally-adjusted ventilatory assist (NAVA) for infants with congenital diaphragmatic hernia (CDH)
AU - Poole, Grace
AU - Shetty, Sandeep
AU - Greenough, Anne
N1 - Funding Information:
The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Funding Information:
Research funding: The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Publisher Copyright:
© 2022 the author(s), published by De Gruyter, Berlin/Boston.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Objectives: Newborns with congenital diaphragmatic hernia (CDH) can have complex respiratory problems which are worsened by ventilatory induced lung injury. Neurally adjusted ventilator assist (NAVA) is a potentially promising ventilation mode for this population, as it can result in improved patient-ventilator interactions and provision of adequate gas exchange at lower airway pressures. Content: A literature review was undertaken to provide an overview of NAVA and examine its role in the management of infants with CDH. Summary: NAVA in neonates has been used in CDH infants who were stable on ventilatory support or being weaned from mechanical ventilation and was associated with a reduction in the level of respiratory support. Outlook: There is, however, limited evidence regarding the efficacy of NAVA in infants with CDH, with only short-term benefits being investigated. A prospective, multicentre study with long term follow-up is required to appropriately assess NAVA in this population.
AB - Objectives: Newborns with congenital diaphragmatic hernia (CDH) can have complex respiratory problems which are worsened by ventilatory induced lung injury. Neurally adjusted ventilator assist (NAVA) is a potentially promising ventilation mode for this population, as it can result in improved patient-ventilator interactions and provision of adequate gas exchange at lower airway pressures. Content: A literature review was undertaken to provide an overview of NAVA and examine its role in the management of infants with CDH. Summary: NAVA in neonates has been used in CDH infants who were stable on ventilatory support or being weaned from mechanical ventilation and was associated with a reduction in the level of respiratory support. Outlook: There is, however, limited evidence regarding the efficacy of NAVA in infants with CDH, with only short-term benefits being investigated. A prospective, multicentre study with long term follow-up is required to appropriately assess NAVA in this population.
KW - congenital diaphragmatic hernia (CDH)
KW - neurally adjusted ventilator assist (NAVA)
KW - patient-ventilator synchrony
UR - http://www.scopus.com/inward/record.url?scp=85141894831&partnerID=8YFLogxK
U2 - 10.1515/jpm-2022-0199
DO - 10.1515/jpm-2022-0199
M3 - Review article
C2 - 35795983
AN - SCOPUS:85141894831
SN - 0300-5577
VL - 50
SP - 1163
EP - 1167
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
IS - 9
ER -