The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients

TY - CHAP

T1 - The Use of PARP Inhibitors in Cancer Therapy

T2 - Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients

AU - Shall, Sydney

AU - Gaymes, Terry

AU - Farzaneh, Farzin

AU - Curtin, Nicola J

AU - Mufti, Ghulam

PY - 2017/7/11

Y1 - 2017/7/11

N2 - This chapter describes some of the techniques in use in our laboratories for the investigation of PARP inhibitors in clinical medicine. More specifically, we are involved in investigating the utility of PARP inhibitors in the treatment of hematopoietic malignancies. We are also actively investigating the properties of the PARP systems in cell biology. We begin the chapter with a very brief history of the invention and use of PARP inhibitors. We then explain the underlying logic of the use of PARP inhibitors either in combination with chemo- or radiotherapy or as single agents used alone. We then provide in full detail the protocols that we use to study PARP inhibitors in cell biology to identify patients that should be susceptible to PARP inhibitor treatment and to manage and investigate these patients throughout their treatment.

AB - This chapter describes some of the techniques in use in our laboratories for the investigation of PARP inhibitors in clinical medicine. More specifically, we are involved in investigating the utility of PARP inhibitors in the treatment of hematopoietic malignancies. We are also actively investigating the properties of the PARP systems in cell biology. We begin the chapter with a very brief history of the invention and use of PARP inhibitors. We then explain the underlying logic of the use of PARP inhibitors either in combination with chemo- or radiotherapy or as single agents used alone. We then provide in full detail the protocols that we use to study PARP inhibitors in cell biology to identify patients that should be susceptible to PARP inhibitor treatment and to manage and investigate these patients throughout their treatment.

KW - Journal Article

U2 - 10.1007/978-1-4939-6993-7_23

DO - 10.1007/978-1-4939-6993-7_23

M3 - Chapter

C2 - 28695521

SN - 978-1-4939-6993-7

VL - 1608

T3 - Methods in Molecular Biology (MIMB)

SP - 343

EP - 370

BT - Poly(ADP-Ribose) Polymerase

PB - Springer

ER -