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The utility of molecular diagnostics to predict recurrence of head and neck carcinoma

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The utility of molecular diagnostics to predict recurrence of head and neck carcinoma. / Pena Murillo, C; Huang, X; Hills, A et al.

In: BJC: British Journal of Cancer, Vol. 107, No. 7, 25.09.2012, p. 1138-1143.

Research output: Contribution to journalArticlepeer-review

Harvard

Pena Murillo, C, Huang, X, Hills, A, McGurk, M, Lyons, A, Jeannon, J-P, Odell, E, Brown, A, Lavery, K, Barrett, W, Sherriff, M, Brakenhoff, R & Partridge, M 2012, 'The utility of molecular diagnostics to predict recurrence of head and neck carcinoma', BJC: British Journal of Cancer, vol. 107, no. 7, pp. 1138-1143. https://doi.org/10.1038/bjc.2012.213

APA

Pena Murillo, C., Huang, X., Hills, A., McGurk, M., Lyons, A., Jeannon, J-P., Odell, E., Brown, A., Lavery, K., Barrett, W., Sherriff, M., Brakenhoff, R., & Partridge, M. (2012). The utility of molecular diagnostics to predict recurrence of head and neck carcinoma. BJC: British Journal of Cancer, 107(7), 1138-1143. https://doi.org/10.1038/bjc.2012.213

Vancouver

Pena Murillo C, Huang X, Hills A, McGurk M, Lyons A, Jeannon J-P et al. The utility of molecular diagnostics to predict recurrence of head and neck carcinoma. BJC: British Journal of Cancer. 2012 Sep 25;107(7):1138-1143. https://doi.org/10.1038/bjc.2012.213

Author

Pena Murillo, C ; Huang, X ; Hills, A et al. / The utility of molecular diagnostics to predict recurrence of head and neck carcinoma. In: BJC: British Journal of Cancer. 2012 ; Vol. 107, No. 7. pp. 1138-1143.

Bibtex Download

@article{97c1b7b789924cfa9a44067098035e47,
title = "The utility of molecular diagnostics to predict recurrence of head and neck carcinoma",
abstract = "Background: Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.Methods: One hundred and two cases with tumour-adjacent margins, considered to be clear margins by microscopy, were examined using carefully optimised molecular diagnostics based on detection of the TP53 and Ly-6D markers. The markers were also combined to provide a dual approach.Results: The dual molecular diagnostic identified cases with a significant increase in the probablility of developing locoregional recurrence when tumour-adjacent positive and clear margins were compared (P=0.0001). These tests were most useful when the clearance at the resection margins was 5 mm or less. The TP53-based diagnostic was a better predictor of locoregional recurrence than established clinicopathological parameters.Conclusion: The optimised TP53-based diagnostic rapidly identifies an important subgroup of cases with close margins that will benefit from new treatment modalities to reduce the risk of recurrence.",
author = "{Pena Murillo}, C and X Huang and A Hills and M McGurk and Andrew Lyons and Jean-Pierre Jeannon and E Odell and A Brown and K Lavery and W Barrett and M Sherriff and R Brakenhoff and M Partridge",
year = "2012",
month = sep,
day = "25",
doi = "10.1038/bjc.2012.213",
language = "English",
volume = "107",
pages = "1138--1143",
journal = "BJC: British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "7",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - The utility of molecular diagnostics to predict recurrence of head and neck carcinoma

AU - Pena Murillo, C

AU - Huang, X

AU - Hills, A

AU - McGurk, M

AU - Lyons, Andrew

AU - Jeannon, Jean-Pierre

AU - Odell, E

AU - Brown, A

AU - Lavery, K

AU - Barrett, W

AU - Sherriff, M

AU - Brakenhoff, R

AU - Partridge, M

PY - 2012/9/25

Y1 - 2012/9/25

N2 - Background: Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.Methods: One hundred and two cases with tumour-adjacent margins, considered to be clear margins by microscopy, were examined using carefully optimised molecular diagnostics based on detection of the TP53 and Ly-6D markers. The markers were also combined to provide a dual approach.Results: The dual molecular diagnostic identified cases with a significant increase in the probablility of developing locoregional recurrence when tumour-adjacent positive and clear margins were compared (P=0.0001). These tests were most useful when the clearance at the resection margins was 5 mm or less. The TP53-based diagnostic was a better predictor of locoregional recurrence than established clinicopathological parameters.Conclusion: The optimised TP53-based diagnostic rapidly identifies an important subgroup of cases with close margins that will benefit from new treatment modalities to reduce the risk of recurrence.

AB - Background: Locoregional recurrence is the major cause of treatment failure after surgery for oral squamous cell carcinoma. Molecular diagnostics have the potential to improve on clinicopathological parameters to predict this recurrence and plan adjuvant treatment. The test most frequently applied is based on detecting TP53 mutations, but alternative methodology is required for cases that harbour the wild-type gene.Methods: One hundred and two cases with tumour-adjacent margins, considered to be clear margins by microscopy, were examined using carefully optimised molecular diagnostics based on detection of the TP53 and Ly-6D markers. The markers were also combined to provide a dual approach.Results: The dual molecular diagnostic identified cases with a significant increase in the probablility of developing locoregional recurrence when tumour-adjacent positive and clear margins were compared (P=0.0001). These tests were most useful when the clearance at the resection margins was 5 mm or less. The TP53-based diagnostic was a better predictor of locoregional recurrence than established clinicopathological parameters.Conclusion: The optimised TP53-based diagnostic rapidly identifies an important subgroup of cases with close margins that will benefit from new treatment modalities to reduce the risk of recurrence.

U2 - 10.1038/bjc.2012.213

DO - 10.1038/bjc.2012.213

M3 - Article

C2 - 22918395

VL - 107

SP - 1138

EP - 1143

JO - BJC: British Journal of Cancer

JF - BJC: British Journal of Cancer

SN - 0007-0920

IS - 7

ER -

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