The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele

J F Setterfield; S Neill; P J Shirlaw; J Theron; R Vaughan; M Escudier; S J Challacombe; M M Black

doi:10.1016/j.jaad.2005.12.006

The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele

J F Setterfield, S Neill, P J Shirlaw, J Theron, R Vaughan, M Escudier, S J Challacombe, M M Black

Centre for Host Microbiome Interactions

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103 Citations (Scopus)

Abstract

Background: The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation. Objective. We sought to define the clinical, immunopathologic, and human leukocyte antigen findings in a large cohort of patients. Methods: The clinical presentation and outcome during long-term follow-tip were documented in 40 patients. In addition, human leukocyte antigen typing for class 11 by polymerase chain reaction and sequence-specific primers was performed. Results: During a mean follow-up period of 8.7 (SD +/- 6.8) years, long-term sequelae included strictures of the esophagus, lachrymal ducts, and external auditory canal; loss Of vulval architecture; vaginal stenosis; and buccal mucosal fibrosis. The DQB1*0201 allele was present in 80% of patients versus 41.8% of control subjects (P

Original language	English
Pages (from-to)	98 - 113
Number of pages	16
Journal	Journal of the American Academy of Dermatology
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/j.jaad.2005.12.006
Publication status	Published - Jul 2006

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Setterfield, J. F., Neill, S., Shirlaw, P. J., Theron, J., Vaughan, R., Escudier, M., Challacombe, S. J., & Black, M. M. (2006). The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele. Journal of the American Academy of Dermatology, 55(1), 98 - 113. https://doi.org/10.1016/j.jaad.2005.12.006

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title = "The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele",

abstract = "Background: The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation. Objective. We sought to define the clinical, immunopathologic, and human leukocyte antigen findings in a large cohort of patients. Methods: The clinical presentation and outcome during long-term follow-tip were documented in 40 patients. In addition, human leukocyte antigen typing for class 11 by polymerase chain reaction and sequence-specific primers was performed. Results: During a mean follow-up period of 8.7 (SD +/- 6.8) years, long-term sequelae included strictures of the esophagus, lachrymal ducts, and external auditory canal; loss Of vulval architecture; vaginal stenosis; and buccal mucosal fibrosis. The DQB1*0201 allele was present in 80% of patients versus 41.8% of control subjects (P ",

author = "Setterfield, {J F} and S Neill and Shirlaw, {P J} and J Theron and R Vaughan and M Escudier and Challacombe, {S J} and Black, {M M}",

year = "2006",

month = jul,

doi = "10.1016/j.jaad.2005.12.006",

language = "English",

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pages = "98 -- 113",

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Setterfield, JF, Neill, S, Shirlaw, PJ, Theron, J, Vaughan, R, Escudier, M , Challacombe, SJ & Black, MM 2006, 'The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele', Journal of the American Academy of Dermatology, vol. 55, no. 1, pp. 98 - 113. https://doi.org/10.1016/j.jaad.2005.12.006

The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele. / Setterfield, J F; Neill, S; Shirlaw, P J et al.
In: Journal of the American Academy of Dermatology, Vol. 55, No. 1, 07.2006, p. 98 - 113.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele

AU - Setterfield, J F

AU - Neill, S

AU - Shirlaw, P J

AU - Theron, J

AU - Vaughan, R

AU - Escudier, M

AU - Challacombe, S J

AU - Black, M M

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AB - Background: The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation. Objective. We sought to define the clinical, immunopathologic, and human leukocyte antigen findings in a large cohort of patients. Methods: The clinical presentation and outcome during long-term follow-tip were documented in 40 patients. In addition, human leukocyte antigen typing for class 11 by polymerase chain reaction and sequence-specific primers was performed. Results: During a mean follow-up period of 8.7 (SD +/- 6.8) years, long-term sequelae included strictures of the esophagus, lachrymal ducts, and external auditory canal; loss Of vulval architecture; vaginal stenosis; and buccal mucosal fibrosis. The DQB1*0201 allele was present in 80% of patients versus 41.8% of control subjects (P

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JO - Journal of the American Academy of Dermatology

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The vulvovaginal gingival syndrome: A severe subgroup of lichen planus with characteristic clinical features and a novel association with the class IIHLA DQB1*0201 allele

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