The Wide World of Coacervates: From the Sea to Neurodegeneration

Emanuele Astoricchio; Caterina Alfano; Lawrie Rajendran; Piero Andrea Temussi; Annalisa Pastore

doi:10.1016/j.tibs.2020.04.006

The Wide World of Coacervates: From the Sea to Neurodegeneration

Emanuele Astoricchio, Caterina Alfano, Lawrie Rajendran, Piero Andrea Temussi, Annalisa Pastore

Basic and Clinical Neuroscience

Research output: Contribution to journal › Review article › peer-review

23 Citations (Scopus)

159 Downloads (Pure)

Abstract

The formation of immiscible liquid phases or coacervates is a phenomenon widely observed in biology. Marine organisms, for instance, use liquid–liquid phase separation (LLPS) as the precursor phase to form various fibrillar or crustaceous materials that are essential for surface adhesion. More recently, the importance of LLPS has been realized in the compartmentalization of living cells and in obtaining ordered but dynamic partitions that can be reversed according to necessity. Here, we compare the properties, features, and peculiarities of intracellular and extracellular coacervates, drawing parallels and learning from the differences. A more general view of the phenomenon may in the future inform new studies to allow a better comprehension of its laws.

Original language	English
Pages (from-to)	706-717
Journal	TRENDS IN BIOCHEMICAL SCIENCES
Volume	45
Issue number	8
Early online date	13 May 2020
DOIs	https://doi.org/10.1016/j.tibs.2020.04.006
Publication status	Published - Aug 2020

Keywords

cellular compartmentalization
confinement
liquid–liquid phase transition
marine organisms
membraneless particles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibs.2020.04.006

The wide world of_ASTORICCHIO_Accepted16Apr20_PublishedAug2020_GREEN AAMAccepted author manuscript, 1.25 MBLicence: CC BY-NC-ND

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abstract = "The formation of immiscible liquid phases or coacervates is a phenomenon widely observed in biology. Marine organisms, for instance, use liquid–liquid phase separation (LLPS) as the precursor phase to form various fibrillar or crustaceous materials that are essential for surface adhesion. More recently, the importance of LLPS has been realized in the compartmentalization of living cells and in obtaining ordered but dynamic partitions that can be reversed according to necessity. Here, we compare the properties, features, and peculiarities of intracellular and extracellular coacervates, drawing parallels and learning from the differences. A more general view of the phenomenon may in the future inform new studies to allow a better comprehension of its laws.",

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T2 - From the Sea to Neurodegeneration

AU - Astoricchio, Emanuele

AU - Alfano, Caterina

AU - Rajendran, Lawrie

AU - Temussi, Piero Andrea

AU - Pastore, Annalisa

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Y1 - 2020/8

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AB - The formation of immiscible liquid phases or coacervates is a phenomenon widely observed in biology. Marine organisms, for instance, use liquid–liquid phase separation (LLPS) as the precursor phase to form various fibrillar or crustaceous materials that are essential for surface adhesion. More recently, the importance of LLPS has been realized in the compartmentalization of living cells and in obtaining ordered but dynamic partitions that can be reversed according to necessity. Here, we compare the properties, features, and peculiarities of intracellular and extracellular coacervates, drawing parallels and learning from the differences. A more general view of the phenomenon may in the future inform new studies to allow a better comprehension of its laws.

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KW - confinement

KW - liquid–liquid phase transition

KW - marine organisms

KW - membraneless particles

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DO - 10.1016/j.tibs.2020.04.006

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The Wide World of Coacervates: From the Sea to Neurodegeneration

Abstract

Keywords

UN SDGs

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