The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain

D L Ellies, V Church, P Francis-West, A Lumsden

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)

Abstract

In the avian hindbrain, the loss of premigratory neural crest cells from rhombomeres 3 and 5 (r3, r5) through programmed cell death contributes to the patterning of emigrant crest cells into three discrete streams. Programmed cell death is induced by the upregulation of Bmp4 and Msx2 in r3 and r5. We show that cSFRP2, a WNT antagonist, is expressed in the even-numbered rhombomeres and that over-expression of cSfrp2 inhibits Bmp4 expression in r3 and r5, preventing programmed cell death. By contrast, depleting cSFRP2 function in r4 results in elevated levels of Msx2 expression and ectopic programmed cell death, as does overexpression of Wnt1. We propose that programmed cell death in the rhombencephalic neural crest is modulated by pre-patterned cSfrp2 expression and a WNT-BMP signalling loop.
Original languageEnglish
Pages (from-to)5285 - 5295
Number of pages11
JournalDevelopment (Cambridge): for advances in developmental biology and stem cells
Volume127
Issue number24
Publication statusPublished - 2000

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