The Wnt Cries Many: Wnt Regulation of Neurogenesis Through Tissue Patterning, Proliferation, and Asymmetric Cell Division

Holger Bielen; Corinne Houart

doi:10.1002/dneu.22168

The Wnt Cries Many: Wnt Regulation of Neurogenesis Through Tissue Patterning, Proliferation, and Asymmetric Cell Division

Holger Bielen^*, Corinne Houart

^*Corresponding author for this work

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

During early development Wnt signaling has a key role in patterning the prospective nervous system by regulation of cell fate specification, cell polarity, and cell migration. Wnt also coordinates the formation of neural circuits on multiple levels such as transcription, cell cycle, and asymmetric cell division. Here we review the latest findings addressing the role of canonical Wnt/beta-catenin signaling during developmental and adult neurogenesis; exploring the connection of in vivo data to the recently described Wnt-driven asymmetric stem cell division in vitro. Understanding how Wnt orchestrates these processes in a spatiotemporal manner during corticogenesis will be of crucial importance for the development of new strategies to regenerate neuronal circuits.

Original language	English
Pages (from-to)	772-780
Number of pages	9
Journal	Developmental Neurobiology
Volume	74
Issue number	8
DOIs	https://doi.org/10.1002/dneu.22168
Publication status	Published - Aug 2014

Keywords

Wnt
neurogenesis
proliferation
asymmetric cell division
telencephalon
EMBRYONIC STEM-CELLS
ADULT HIPPOCAMPAL NEUROGENESIS
MIDBRAIN DOPAMINERGIC-NEURONS
WNT/BETA-CATENIN PATHWAY
BETA-CATENIN
CEREBRAL-CORTEX
C. ELEGANS
IN-VIVO
INTERMEDIATE PROGENITORS
FOREBRAIN DEVELOPMENT

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10.1002/dneu.22168

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title = "The Wnt Cries Many: Wnt Regulation of Neurogenesis Through Tissue Patterning, Proliferation, and Asymmetric Cell Division",

abstract = "During early development Wnt signaling has a key role in patterning the prospective nervous system by regulation of cell fate specification, cell polarity, and cell migration. Wnt also coordinates the formation of neural circuits on multiple levels such as transcription, cell cycle, and asymmetric cell division. Here we review the latest findings addressing the role of canonical Wnt/beta-catenin signaling during developmental and adult neurogenesis; exploring the connection of in vivo data to the recently described Wnt-driven asymmetric stem cell division in vitro. Understanding how Wnt orchestrates these processes in a spatiotemporal manner during corticogenesis will be of crucial importance for the development of new strategies to regenerate neuronal circuits.",

keywords = "Wnt, neurogenesis, proliferation, asymmetric cell division, telencephalon, EMBRYONIC STEM-CELLS, ADULT HIPPOCAMPAL NEUROGENESIS, MIDBRAIN DOPAMINERGIC-NEURONS, WNT/BETA-CATENIN PATHWAY, BETA-CATENIN, CEREBRAL-CORTEX, C. ELEGANS, IN-VIVO, INTERMEDIATE PROGENITORS, FOREBRAIN DEVELOPMENT",

author = "Holger Bielen and Corinne Houart",

year = "2014",

month = aug,

doi = "10.1002/dneu.22168",

language = "English",

volume = "74",

pages = "772--780",

journal = "Developmental Neurobiology",

issn = "1932-8451",

publisher = "John Wiley and Sons Inc.",

number = "8",

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T1 - The Wnt Cries Many

T2 - Wnt Regulation of Neurogenesis Through Tissue Patterning, Proliferation, and Asymmetric Cell Division

AU - Bielen, Holger

AU - Houart, Corinne

PY - 2014/8

Y1 - 2014/8

N2 - During early development Wnt signaling has a key role in patterning the prospective nervous system by regulation of cell fate specification, cell polarity, and cell migration. Wnt also coordinates the formation of neural circuits on multiple levels such as transcription, cell cycle, and asymmetric cell division. Here we review the latest findings addressing the role of canonical Wnt/beta-catenin signaling during developmental and adult neurogenesis; exploring the connection of in vivo data to the recently described Wnt-driven asymmetric stem cell division in vitro. Understanding how Wnt orchestrates these processes in a spatiotemporal manner during corticogenesis will be of crucial importance for the development of new strategies to regenerate neuronal circuits.

AB - During early development Wnt signaling has a key role in patterning the prospective nervous system by regulation of cell fate specification, cell polarity, and cell migration. Wnt also coordinates the formation of neural circuits on multiple levels such as transcription, cell cycle, and asymmetric cell division. Here we review the latest findings addressing the role of canonical Wnt/beta-catenin signaling during developmental and adult neurogenesis; exploring the connection of in vivo data to the recently described Wnt-driven asymmetric stem cell division in vitro. Understanding how Wnt orchestrates these processes in a spatiotemporal manner during corticogenesis will be of crucial importance for the development of new strategies to regenerate neuronal circuits.

KW - Wnt

KW - neurogenesis

KW - proliferation

KW - asymmetric cell division

KW - telencephalon

KW - EMBRYONIC STEM-CELLS

KW - ADULT HIPPOCAMPAL NEUROGENESIS

KW - MIDBRAIN DOPAMINERGIC-NEURONS

KW - WNT/BETA-CATENIN PATHWAY

KW - BETA-CATENIN

KW - CEREBRAL-CORTEX

KW - C. ELEGANS

KW - IN-VIVO

KW - INTERMEDIATE PROGENITORS

KW - FOREBRAIN DEVELOPMENT

U2 - 10.1002/dneu.22168

DO - 10.1002/dneu.22168

M3 - Article

SN - 1932-8451

VL - 74

SP - 772

EP - 780

JO - Developmental Neurobiology

JF - Developmental Neurobiology

IS - 8

ER -

The Wnt Cries Many: Wnt Regulation of Neurogenesis Through Tissue Patterning, Proliferation, and Asymmetric Cell Division

Abstract

Keywords

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