The X11/Mint family of adaptor proteins

TY - JOUR

T1 - The X11/Mint family of adaptor proteins

AU - Rogelj, B

AU - Mitchell, J C

AU - Miller, C C J

AU - McLoughlin, D M

PY - 2006/9

Y1 - 2006/9

N2 - The X11 protein family are multidomain proteins composed of a conserved PTB domain and two C-terminal PDZ domains. They are involved in formation of multiprotein complexes and two of the family members, X11 alpha and X11 beta, are expressed primarily in neurones. Not much is known about the principal function of X11s, but through interactions with other neuronal proteins, they are believed to be involved in regulating neuronal signaling, trafficking and plasticity. Furthermore, they have been shown to modulate processing of APT and accumulation of A, making them potential therapeutic targets for Alzheimer's disease. This article reviews the known interactions of the different X11s and their involvement in Alzheimer's disease. (c) 2006 Elsevier B.V. All rights reserved

AB - The X11 protein family are multidomain proteins composed of a conserved PTB domain and two C-terminal PDZ domains. They are involved in formation of multiprotein complexes and two of the family members, X11 alpha and X11 beta, are expressed primarily in neurones. Not much is known about the principal function of X11s, but through interactions with other neuronal proteins, they are believed to be involved in regulating neuronal signaling, trafficking and plasticity. Furthermore, they have been shown to modulate processing of APT and accumulation of A, making them potential therapeutic targets for Alzheimer's disease. This article reviews the known interactions of the different X11s and their involvement in Alzheimer's disease. (c) 2006 Elsevier B.V. All rights reserved

U2 - 10.1016/j.brainresrev.2006.04.005

DO - 10.1016/j.brainresrev.2006.04.005

M3 - Literature review

VL - 52

SP - 305

EP - 315

JO - Brain Research Reviews

JF - Brain Research Reviews

IS - 2

ER -