Theoretical models for coronary vascular biomechanics: Progress & challenges

SL Waters; Jordi Alastruey; DA Beard; PHM Bovendeerd; PF Davies; G Jayaraman; OE Jensen; J Lee; KH Parker; AS Pople; TW Secomb; SJ Sherwin; RJ Shipley; NP Smith; F van de Vosse

doi:10.1016/j.pbiomolbio.2010.10.001

Theoretical models for coronary vascular biomechanics: Progress & challenges

SL Waters, Jordi Alastruey, DA Beard, PHM Bovendeerd, PF Davies, G Jayaraman, OE Jensen, J Lee, KH Parker, AS Pople, TW Secomb, SJ Sherwin, RJ Shipley, NP Smith, F van de Vosse

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research. We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.

Original language	English
Pages (from-to)	49 - 76
Number of pages	28
Journal	Progress in Biophysics and Molecular Biology
Volume	104
Issue number	1-3
DOIs	https://doi.org/10.1016/j.pbiomolbio.2010.10.001
Publication status	Published - Jan 2011

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Waters, SL., Alastruey, J., Beard, DA., Bovendeerd, PHM., Davies, PF., Jayaraman, G., Jensen, OE., Lee, J., Parker, KH., Pople, AS., Secomb, TW., Sherwin, SJ., Shipley, RJ., Smith, NP., & van de Vosse, F. (2011). Theoretical models for coronary vascular biomechanics: Progress & challenges. Progress in Biophysics and Molecular Biology, 104(1-3), 49 - 76. https://doi.org/10.1016/j.pbiomolbio.2010.10.001

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title = "Theoretical models for coronary vascular biomechanics: Progress & challenges",

abstract = "A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research. We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.",

author = "SL Waters and Jordi Alastruey and DA Beard and PHM Bovendeerd and PF Davies and G Jayaraman and OE Jensen and J Lee and KH Parker and AS Pople and TW Secomb and SJ Sherwin and RJ Shipley and NP Smith and {van de Vosse}, F",

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Waters, SL, Alastruey, J, Beard, DA, Bovendeerd, PHM, Davies, PF, Jayaraman, G, Jensen, OE, Lee, J, Parker, KH, Pople, AS, Secomb, TW, Sherwin, SJ, Shipley, RJ, Smith, NP & van de Vosse, F 2011, 'Theoretical models for coronary vascular biomechanics: Progress & challenges', Progress in Biophysics and Molecular Biology, vol. 104, no. 1-3, pp. 49 - 76. https://doi.org/10.1016/j.pbiomolbio.2010.10.001

TY - JOUR

T1 - Theoretical models for coronary vascular biomechanics

T2 - Progress & challenges

AU - Waters, SL

AU - Alastruey, Jordi

AU - Beard, DA

AU - Bovendeerd, PHM

AU - Davies, PF

AU - Jayaraman, G

AU - Jensen, OE

AU - Lee, J

AU - Parker, KH

AU - Pople, AS

AU - Secomb, TW

AU - Sherwin, SJ

AU - Shipley, RJ

AU - Smith, NP

AU - van de Vosse, F

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N2 - A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research. We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.

AB - A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research. We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.

U2 - 10.1016/j.pbiomolbio.2010.10.001

DO - 10.1016/j.pbiomolbio.2010.10.001

M3 - Article

SN - 0079-6107

VL - 104

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EP - 76

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

IS - 1-3

ER -

Theoretical models for coronary vascular biomechanics: Progress & challenges

Abstract

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