Therapeutic interventions after spinal cord injury

Research output: Contribution to journalArticlepeer-review

845 Citations (Scopus)

Abstract

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have been tested in animal models. Many of these have reached, or are approaching, clinical trials. Here, we review these potential therapies, with an emphasis on the need for reproducible evidence of safety and efficacy. Individual therapies are unlikely to provide a panacea. Rather, we predict that combinations of strategies will lead to improvements in outcome after SCI. Basic scientific research should provide a rational basis for tailoring specific combinations of clinical therapies to different types of SCI.
Original languageEnglish
Pages (from-to)628 - 643
Number of pages16
JournalNATURE REVIEWS NEUROSCIENCE
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 2006

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