Therapeutic Potential of Ferulic Acid in Alzheimer's Disease

Hasan Turkez; Mehmet Enes Arslan; Joice Nascimento Barboza; Cigdem Yuce Kahraman; Damiao Pergentino de Sousa; Adil Mardinoğlu

doi:10.2174/1567201819666211228153801

Therapeutic Potential of Ferulic Acid in Alzheimer's Disease

Hasan Turkez^*, Mehmet Enes Arslan, Joice Nascimento Barboza, Cigdem Yuce Kahraman, Damiao Pergentino de Sousa, Adil Mardinoğlu

^*Corresponding author for this work

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases, ac-counting for 60% of all dementia cases. AD is a progressive neurodegenerative disease that occurs due to the production of β-amyloid (Aβ) protein and accumulation of hyper-phosphorylated tau pro-tein; it causes breakage in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment, or slowing down its progression. Over the last decade, multiple target applications have been devel-oped for AD treatments. These targets include Aβ accumulations, hyper-phosphorylated tau pro-teins, mitochondrial dysfunction, and oxidative stress, resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from Aβ-induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity an-tioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflamma-tory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerts neuroprotection via preventing Aβ-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in preventing Aβ-induced neurotoxicity, protecting against free radical attacks, and exhibiting enzyme inhibitions and evaluate them as possible therapeutic agents for the treatment of AD.

Original language	English
Pages (from-to)	860-873
Number of pages	14
Journal	Current Drug Delivery
Volume	19
Issue number	8
DOIs	https://doi.org/10.2174/1567201819666211228153801
Publication status	Published - 10 Feb 2022

Keywords

Alzheimer’s disease
amyloid-beta
anti-Alzheimer
drug candidate
experimental Alzheimer’s model
Ferulic acid
neuroprotection
neurotoxicity

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10.2174/1567201819666211228153801

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title = "Therapeutic Potential of Ferulic Acid in Alzheimer's Disease",

abstract = "Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases, ac-counting for 60% of all dementia cases. AD is a progressive neurodegenerative disease that occurs due to the production of β-amyloid (Aβ) protein and accumulation of hyper-phosphorylated tau pro-tein; it causes breakage in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment, or slowing down its progression. Over the last decade, multiple target applications have been devel-oped for AD treatments. These targets include Aβ accumulations, hyper-phosphorylated tau pro-teins, mitochondrial dysfunction, and oxidative stress, resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from Aβ-induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity an-tioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflamma-tory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerts neuroprotection via preventing Aβ-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in preventing Aβ-induced neurotoxicity, protecting against free radical attacks, and exhibiting enzyme inhibitions and evaluate them as possible therapeutic agents for the treatment of AD.",

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author = "Hasan Turkez and Arslan, {Mehmet Enes} and Barboza, {Joice Nascimento} and Kahraman, {Cigdem Yuce} and {de Sousa}, {Damiao Pergentino} and Adil Mardinoğlu",

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T1 - Therapeutic Potential of Ferulic Acid in Alzheimer's Disease

AU - Turkez, Hasan

AU - Arslan, Mehmet Enes

AU - Barboza, Joice Nascimento

AU - Kahraman, Cigdem Yuce

AU - de Sousa, Damiao Pergentino

AU - Mardinoğlu, Adil

PY - 2022/2/10

Y1 - 2022/2/10

N2 - Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases, ac-counting for 60% of all dementia cases. AD is a progressive neurodegenerative disease that occurs due to the production of β-amyloid (Aβ) protein and accumulation of hyper-phosphorylated tau pro-tein; it causes breakage in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment, or slowing down its progression. Over the last decade, multiple target applications have been devel-oped for AD treatments. These targets include Aβ accumulations, hyper-phosphorylated tau pro-teins, mitochondrial dysfunction, and oxidative stress, resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from Aβ-induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity an-tioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflamma-tory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerts neuroprotection via preventing Aβ-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in preventing Aβ-induced neurotoxicity, protecting against free radical attacks, and exhibiting enzyme inhibitions and evaluate them as possible therapeutic agents for the treatment of AD.

AB - Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases, ac-counting for 60% of all dementia cases. AD is a progressive neurodegenerative disease that occurs due to the production of β-amyloid (Aβ) protein and accumulation of hyper-phosphorylated tau pro-tein; it causes breakage in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment, or slowing down its progression. Over the last decade, multiple target applications have been devel-oped for AD treatments. These targets include Aβ accumulations, hyper-phosphorylated tau pro-teins, mitochondrial dysfunction, and oxidative stress, resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from Aβ-induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity an-tioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflamma-tory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerts neuroprotection via preventing Aβ-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in preventing Aβ-induced neurotoxicity, protecting against free radical attacks, and exhibiting enzyme inhibitions and evaluate them as possible therapeutic agents for the treatment of AD.

KW - Alzheimer’s disease

KW - amyloid-beta

KW - anti-Alzheimer

KW - drug candidate

KW - experimental Alzheimer’s model

KW - Ferulic acid

KW - neuroprotection

KW - neurotoxicity

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U2 - 10.2174/1567201819666211228153801

DO - 10.2174/1567201819666211228153801

M3 - Review article

C2 - 34963433

AN - SCOPUS:85132452734

SN - 1567-2018

VL - 19

SP - 860

EP - 873

JO - Current Drug Delivery

JF - Current Drug Delivery

IS - 8

ER -

Therapeutic Potential of Ferulic Acid in Alzheimer's Disease

Abstract

Keywords

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