Therapeutic targets and new directions for antibodies developed for ovarian cancer

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
248 Downloads (Pure)

Abstract

Antibody therapeutics against different target antigens are widely used in the treatment of different malignancies including ovarian carcinomas, but this disease still requires more effective agents. Improved understanding of the biological features, signaling pathways, and immunological escape mechanisms involved in ovarian cancer has emerged in the past few years. These advances, including an appreciation of the cross-talk between cancer cells and the patient's immune system, have led to the identification of new targets. In turn, potential antibody treatments with various mechanisms of action, including immune activation or toxin-delivery, that are directed at these targets have been developed. Here, we identify established as well as novel targets for antibodies in ovarian cancer, and discuss how they may provide fresh opportunities to identify interventions with enhanced therapeutic potential.

Original languageEnglish
Pages (from-to)1437-1455
JournalMabs
Volume8
Issue number8
Early online date10 Sept 2016
DOIs
Publication statusPublished - 2016

Fingerprint

Dive into the research topics of 'Therapeutic targets and new directions for antibodies developed for ovarian cancer'. Together they form a unique fingerprint.

Cite this