@article{b35e8702a1f946f4838f77e1111f3f8b,
title = "Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis",
abstract = "There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.",
keywords = "CBT, Panic disorder, Serotonin transporter gene, Therapy outcome, Therapygenetics, Treatment response",
author = "Schiele, {Miriam A.} and Andreas Reif and Jiaxi Lin and Alpers, {Georg W.} and Evelyn Andersson and Gerhard Andersson and Volker Arolt and Jan Bergstr{\"o}m and Per Carlbring and Eley, {Thalia C.} and Gabriel Esquivel and Tomas Furmark and Gerlach, {Alexander L.} and Alfons Hamm and Sylvia Helbig-Lang and Hudson, {Jennifer L.} and Thomas Lang and Lester, {Kathryn J.} and Nils Lindefors and Lonsdorf, {Tina B.} and Paul Pauli and Jan Richter and Winfried Rief and Susanna Roberts and Christian R{\"u}ck and Schruers, {Koen R.J.} and Christiane Thiel and Wittchen, {Hans Ulrich} and Katharina Domschke and Heike Weber and Ulrike Lueken",
note = "Funding Information: This work was supported by the German Research Foundation (DFG) ? Project No. 44541416 ? TRR 58, projects C02 (to KD), C09 (to UL) and Z02 (to AR, KD, PP, TBL and UL), SFB 1193 Z03 (to AR), and the German Ministry of Research and Education (BMBF, 01EE1402F, PROTECT-AD, P5 to KD).This work was partly funded by a grant from the UK Medical Research Council to TC Eley (G0901874).The study is in part funded by the German Federal Ministry of Education and Research (BMBF, 01GV0614) as part of the larger BMBF Psychotherapy Research Funding Initiative Improving the Treatment of Panic Disorder. Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.euroneuro.2021.01.004",
language = "English",
volume = "44",
pages = "105--120",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
}
