Thermosensitive, Near-Infrared-Labeled Nanoparticles for Topotecan Delivery to Tumors

Elena V. Rosca, Michael Wright, Roman Gonitel, Wladyslaw Gedroyc, Andrew D. Miller, Maya Thanou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Liposomal nanoparticles have proven to be versatile systems for drug delivery. However, the progress in clinic has been slower and less efficient than expected. This suggests a need for further development using carefully designed chemical components to improve usefulness under clinical conditions and maximize therapeutic effect. For cancer chemotherapy, PEGylated liposomes were the first nano-medicine to reach the market and have been used clinically for several years. Approaches toward targeted drug delivery using next generation "thermally triggered" nanoparticles are now in clinical trials. However, clinically tested thermosensitive liposomes (TSLs) lack the markers that allow tumor labeling improved imaging for tissue specific applied hyperthernia. Here we describe the development of optically labeled TSLs for image guidance drug delivery and proof-of-concept results for their application in the treatment of murine xenograft tumors using the anticancer drug topotecan. These labeled TSLs also allow the simultaneous, real-time diagnostic imaging of nanoparticle biodistribution using a near-infrared (NIR; 750-950 nm) fluorophore coupled to a lipidic component of the lipid bilayer. When combined with multispectral fluorescence analysis, this allows for specific and high sensitivity tracking of the nanoparticles in vivo. The application of NIR fluorescence-labeled TSLs could have a transformative effect on future cancer chemotherapy.
Original languageEnglish
Pages (from-to)1335-1346
Number of pages12
JournalMolecular Pharmaceutics
Volume12
Issue number5
Early online date20 Apr 2015
DOIs
Publication statusPublished - 4 May 2015

Keywords

  • thermosensitive liposomes
  • topotecan
  • anticancer
  • focused ultrasound
  • multispectral fluorescence imaging
  • INTENSITY FOCUSED ULTRASOUND
  • TEMPERATURE-SENSITIVE LIPOSOMES
  • TARGETED DRUG-DELIVERY
  • IN-VIVO
  • MILD HYPERTHERMIA
  • SOLID TUMORS
  • ENHANCED PERMEABILITY
  • ANTITUMOR-ACTIVITY
  • CONTROLLED-RELEASE
  • TRIGGERED RELEASE

Fingerprint

Dive into the research topics of 'Thermosensitive, Near-Infrared-Labeled Nanoparticles for Topotecan Delivery to Tumors'. Together they form a unique fingerprint.

Cite this