Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E. Elks; John R. B. Perry; Patrick Sulem; Daniel I. Chasman; Nora Franceschini; Chunyan He; Kathryn L. Lunetta; Jenny A. Visser; Enda M. Byrne; Diana L. Cousminer; Daniel F. Gudbjartsson; Tonu Esko; Bjarke Feenstra; Jouke-Jan Hottenga; Daniel L. Koller; Zoltan Kutalik; Peng Lin; Massimo Mangino; Mara Marongiu; Patrick F. McArdle; Albert V. Smith; Lisette Stolk; Sophie H. Van Wingerden; Jing Hua Zhao; Eva Albrecht; Tanguy Corre; Erik Ingelsson; Caroline Hayward; Patrik K. E. Magnusson; Erin N. Smith; Shelia Ulivi; Nicole M. Warrington; Lina Zgaga; Helen Alavere; Najaf Amin; Thor Aspelund; Stefania Bandinelli; Ines Barroso; Gerald S. Berenson; Sven Bergmann; Hannah Blackburn; Eric Boerwinkle; Julie E. Buring; Fabio Busonero; Harry Campbell; Stephen J. Chanock; Wei Chen; Marilyn C. Cornelis; David Couper; Andrea D. Coviello; Pio d&apos;Adamo; Ulf de Faire; Eco J. C. de Geus; Panos Deloukas; Angela Doering; George Davey Smith; Douglas F. Easton; Gudny Eiriksdottir; Valur Emilsson; Johan Eriksson; Luigi Ferrucci; Aaron R. Folsom; Tatiana Foroud; Melissa Garcia; Paolo Gasparini; Frank Geller; Christian Gieger; Vilmundur Gudnason; Per Hall; Susan E. Hankinson; Liana Ferreli; Andrew C. Heath; Dena G. Hernandez; Albert Hofman; Frank B. Hu; Thomas Illig; Marjo-Riitta Jaervelin; Andrew D. Johnson; David Karasik; Kay-Tee Khaw; Douglas P. Kiel; Tuomas O. Kilpelaeinen; Ivana Kolcic; Peter Kraft; Lenore J. Launer; Joop S. E. Laven; Shengxu Li; Jianjun Liu; Daniel Levy; Nicholas G. Martin; Wendy L. McArdle; Mads Melbye; Vincent Mooser; Jeffrey C. Murray; Sarah S. Murray; Michael A. Nalls; Pau Navarro; Mari Nelis; Andrew R. Ness; Kate Northstone; Ben A. Oostra; Munro Peacock; Lyle J. Palmer; Aarno Palotie; Guillaume Pare; Alex N. Parker; Nancy L. Pedersen; Leena Peltonen; Craig E. Pennell; Paul Pharoah; Ozren Polasek; Andrew S. Plump; Anneli Pouta; Eleonora Porcu; Thorunn Rafnar; John P. Rice; Susan M. Ring; Fernando Rivadeneira; Igor Rudan; Cinzia Sala; Veikko Salomaa; Serena Sanna; David Schlessinger; Nicholas J. Schork; Angelo Scuteri; Ayellet V. Segre; Alan R. Shuldiner; Nicole Soranzo; Ulla Sovio; Sathanur R. Srinivasan; David P. Strachan; Mar-Liis Tammesoo; Emmi Tikkanen; Daniela Toniolo; Kim Tsui; Laufey Tryggvadottir; Jonathon Tyrer; Manuela Uda; Rob M. van Dam; Joyce B. J. van Meurs; Peter Vollenweider; Gerard Waeber; Nicholas J. Wareham; Dawn M. Waterworth; Michael N. Weedon; H. Erich Wichmann; Gonneke Willemsen; James F. Wilson; Alan F. Wright; Lauren Young; Guangju Zhai; Wei Vivian Zhuang; Laura J. Bierut; Dorret I. Boomsma; Heather A. Boyd; Laura Crisponi; Ellen W. Demerath; Cornelia M. van Duijn; Michael J. Econs; Tamara B. Harris; David J. Hunter; Ruth J. F. Loos; Andres Metspalu; Grant W. Montgomery; Paul M. Ridker; Tim D. Spector; Elizabeth A. Streeten; Kari Stefansson; Unnur Thorsteinsdottir; Andre G. Uitterlinden; Elisabeth Widen; Joanne M. Murabito; Ken K. Ong; Anna Murray

doi:10.1038/ng.714

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E. Elks, John R. B. Perry, Patrick Sulem, Daniel I. Chasman, Nora Franceschini, Chunyan He, Kathryn L. Lunetta, Jenny A. Visser, Enda M. Byrne, Diana L. Cousminer, Daniel F. Gudbjartsson, Tonu Esko, Bjarke Feenstra, Jouke-Jan Hottenga, Daniel L. Koller, Zoltan Kutalik, Peng Lin, Massimo Mangino, Mara Marongiu, Patrick F. McArdleAlbert V. Smith, Lisette Stolk, Sophie H. Van Wingerden, Jing Hua Zhao, Eva Albrecht, Tanguy Corre, Erik Ingelsson, Caroline Hayward, Patrik K. E. Magnusson, Erin N. Smith, Shelia Ulivi, Nicole M. Warrington, Lina Zgaga, Helen Alavere, Najaf Amin, Thor Aspelund, Stefania Bandinelli, Ines Barroso, Gerald S. Berenson, Sven Bergmann, Hannah Blackburn, Eric Boerwinkle, Julie E. Buring, Fabio Busonero, Harry Campbell, Stephen J. Chanock, Wei Chen, Marilyn C. Cornelis, David Couper, Andrea D. Coviello, Pio d'Adamo, Ulf de Faire, Eco J. C. de Geus, Panos Deloukas, Angela Doering, George Davey Smith, Douglas F. Easton, Gudny Eiriksdottir, Valur Emilsson, Johan Eriksson, Luigi Ferrucci, Aaron R. Folsom, Tatiana Foroud, Melissa Garcia, Paolo Gasparini, Frank Geller, Christian Gieger, Vilmundur Gudnason, Per Hall, Susan E. Hankinson, Liana Ferreli, Andrew C. Heath, Dena G. Hernandez, Albert Hofman, Frank B. Hu, Thomas Illig, Marjo-Riitta Jaervelin, Andrew D. Johnson, David Karasik, Kay-Tee Khaw, Douglas P. Kiel, Tuomas O. Kilpelaeinen, Ivana Kolcic, Peter Kraft, Lenore J. Launer, Joop S. E. Laven, Shengxu Li, Jianjun Liu, Daniel Levy, Nicholas G. Martin, Wendy L. McArdle, Mads Melbye, Vincent Mooser, Jeffrey C. Murray, Sarah S. Murray, Michael A. Nalls, Pau Navarro, Mari Nelis, Andrew R. Ness, Kate Northstone, Ben A. Oostra, Munro Peacock, Lyle J. Palmer, Aarno Palotie, Guillaume Pare, Alex N. Parker, Nancy L. Pedersen, Leena Peltonen, Craig E. Pennell, Paul Pharoah, Ozren Polasek, Andrew S. Plump, Anneli Pouta, Eleonora Porcu, Thorunn Rafnar, John P. Rice, Susan M. Ring, Fernando Rivadeneira, Igor Rudan, Cinzia Sala, Veikko Salomaa, Serena Sanna, David Schlessinger, Nicholas J. Schork, Angelo Scuteri, Ayellet V. Segre, Alan R. Shuldiner, Nicole Soranzo, Ulla Sovio, Sathanur R. Srinivasan, David P. Strachan, Mar-Liis Tammesoo, Emmi Tikkanen, Daniela Toniolo, Kim Tsui, Laufey Tryggvadottir, Jonathon Tyrer, Manuela Uda, Rob M. van Dam, Joyce B. J. van Meurs, Peter Vollenweider, Gerard Waeber, Nicholas J. Wareham, Dawn M. Waterworth, Michael N. Weedon, H. Erich Wichmann, Gonneke Willemsen, James F. Wilson, Alan F. Wright, Lauren Young, Guangju Zhai, Wei Vivian Zhuang, Laura J. Bierut, Dorret I. Boomsma, Heather A. Boyd, Laura Crisponi, Ellen W. Demerath, Cornelia M. van Duijn, Michael J. Econs, Tamara B. Harris, David J. Hunter, Ruth J. F. Loos, Andres Metspalu, Grant W. Montgomery, Paul M. Ridker, Tim D. Spector, Elizabeth A. Streeten, Kari Stefansson, Unnur Thorsteinsdottir, Andre G. Uitterlinden, Elisabeth Widen, Joanne M. Murabito, Ken K. Ong, Anna Murray

Research output: Contribution to journal › Article › peer-review

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Abstract

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P <5 x 10(-8)) and found suggestive evidence for a further 10 loci (P <1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

Original language	English
Pages (from-to)	1077 - U73
Number of pages	9
Journal	Nature Genetics
Volume	42
Issue number	12
DOIs	https://doi.org/10.1038/ng.714
Publication status	Published - Dec 2010

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Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., Hottenga, J.-J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., ... Murray, A. (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077 - U73. https://doi.org/10.1038/ng.714

@article{95938cd9eeb74ccdac7f6bbe97ae6b26,

title = "Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies",

abstract = "To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P <5 x 10(-8)) and found suggestive evidence for a further 10 loci (P <1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.",

author = "Elks, {Cathy E.} and Perry, {John R. B.} and Patrick Sulem and Chasman, {Daniel I.} and Nora Franceschini and Chunyan He and Lunetta, {Kathryn L.} and Visser, {Jenny A.} and Byrne, {Enda M.} and Cousminer, {Diana L.} and Gudbjartsson, {Daniel F.} and Tonu Esko and Bjarke Feenstra and Jouke-Jan Hottenga and Koller, {Daniel L.} and Zoltan Kutalik and Peng Lin and Massimo Mangino and Mara Marongiu and McArdle, {Patrick F.} and Smith, {Albert V.} and Lisette Stolk and {Van Wingerden}, {Sophie H.} and Zhao, {Jing Hua} and Eva Albrecht and Tanguy Corre and Erik Ingelsson and Caroline Hayward and Magnusson, {Patrik K. E.} and Smith, {Erin N.} and Shelia Ulivi and Warrington, {Nicole M.} and Lina Zgaga and Helen Alavere and Najaf Amin and Thor Aspelund and Stefania Bandinelli and Ines Barroso and Berenson, {Gerald S.} and Sven Bergmann and Hannah Blackburn and Eric Boerwinkle and Buring, {Julie E.} and Fabio Busonero and Harry Campbell and Chanock, {Stephen J.} and Wei Chen and Cornelis, {Marilyn C.} and David Couper and Coviello, {Andrea D.} and Pio d'Adamo and {de Faire}, Ulf and {de Geus}, {Eco J. C.} and Panos Deloukas and Angela Doering and Smith, {George Davey} and Easton, {Douglas F.} and Gudny Eiriksdottir and Valur Emilsson and Johan Eriksson and Luigi Ferrucci and Folsom, {Aaron R.} and Tatiana Foroud and Melissa Garcia and Paolo Gasparini and Frank Geller and Christian Gieger and Vilmundur Gudnason and Per Hall and Hankinson, {Susan E.} and Liana Ferreli and Heath, {Andrew C.} and Hernandez, {Dena G.} and Albert Hofman and Hu, {Frank B.} and Thomas Illig and Marjo-Riitta Jaervelin and Johnson, {Andrew D.} and David Karasik and Kay-Tee Khaw and Kiel, {Douglas P.} and Kilpelaeinen, {Tuomas O.} and Ivana Kolcic and Peter Kraft and Launer, {Lenore J.} and Laven, {Joop S. E.} and Shengxu Li and Jianjun Liu and Daniel Levy and Martin, {Nicholas G.} and McArdle, {Wendy L.} and Mads Melbye and Vincent Mooser and Murray, {Jeffrey C.} and Murray, {Sarah S.} and Nalls, {Michael A.} and Pau Navarro and Mari Nelis and Ness, {Andrew R.} and Kate Northstone and Oostra, {Ben A.} and Munro Peacock and Palmer, {Lyle J.} and Aarno Palotie and Guillaume Pare and Parker, {Alex N.} and Pedersen, {Nancy L.} and Leena Peltonen and Pennell, {Craig E.} and Paul Pharoah and Ozren Polasek and Plump, {Andrew S.} and Anneli Pouta and Eleonora Porcu and Thorunn Rafnar and Rice, {John P.} and Ring, {Susan M.} and Fernando Rivadeneira and Igor Rudan and Cinzia Sala and Veikko Salomaa and Serena Sanna and David Schlessinger and Schork, {Nicholas J.} and Angelo Scuteri and Segre, {Ayellet V.} and Shuldiner, {Alan R.} and Nicole Soranzo and Ulla Sovio and Srinivasan, {Sathanur R.} and Strachan, {David P.} and Mar-Liis Tammesoo and Emmi Tikkanen and Daniela Toniolo and Kim Tsui and Laufey Tryggvadottir and Jonathon Tyrer and Manuela Uda and {van Dam}, {Rob M.} and {van Meurs}, {Joyce B. J.} and Peter Vollenweider and Gerard Waeber and Wareham, {Nicholas J.} and Waterworth, {Dawn M.} and Weedon, {Michael N.} and Wichmann, {H. Erich} and Gonneke Willemsen and Wilson, {James F.} and Wright, {Alan F.} and Lauren Young and Guangju Zhai and Zhuang, {Wei Vivian} and Bierut, {Laura J.} and Boomsma, {Dorret I.} and Boyd, {Heather A.} and Laura Crisponi and Demerath, {Ellen W.} and {van Duijn}, {Cornelia M.} and Econs, {Michael J.} and Harris, {Tamara B.} and Hunter, {David J.} and Loos, {Ruth J. F.} and Andres Metspalu and Montgomery, {Grant W.} and Ridker, {Paul M.} and Spector, {Tim D.} and Streeten, {Elizabeth A.} and Kari Stefansson and Unnur Thorsteinsdottir and Uitterlinden, {Andre G.} and Elisabeth Widen and Murabito, {Joanne M.} and Ong, {Ken K.} and Anna Murray",

year = "2010",

month = dec,

doi = "10.1038/ng.714",

language = "English",

volume = "42",

pages = "1077 -- U73",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Research",

number = "12",

}

Elks, CE, Perry, JRB, Sulem, P, Chasman, DI, Franceschini, N, He, C, Lunetta, KL, Visser, JA, Byrne, EM, Cousminer, DL, Gudbjartsson, DF, Esko, T, Feenstra, B, Hottenga, J-J, Koller, DL, Kutalik, Z, Lin, P, Mangino, M, Marongiu, M, McArdle, PF, Smith, AV, Stolk, L, Van Wingerden, SH, Zhao, JH, Albrecht, E, Corre, T, Ingelsson, E, Hayward, C, Magnusson, PKE, Smith, EN, Ulivi, S, Warrington, NM, Zgaga, L, Alavere, H, Amin, N, Aspelund, T, Bandinelli, S, Barroso, I, Berenson, GS, Bergmann, S, Blackburn, H, Boerwinkle, E, Buring, JE, Busonero, F, Campbell, H, Chanock, SJ, Chen, W, Cornelis, MC, Couper, D, Coviello, AD, d'Adamo, P, de Faire, U, de Geus, EJC, Deloukas, P, Doering, A, Smith, GD, Easton, DF, Eiriksdottir, G, Emilsson, V, Eriksson, J, Ferrucci, L, Folsom, AR, Foroud, T, Garcia, M, Gasparini, P, Geller, F, Gieger, C, Gudnason, V, Hall, P, Hankinson, SE, Ferreli, L, Heath, AC, Hernandez, DG, Hofman, A, Hu, FB, Illig, T, Jaervelin, M-R, Johnson, AD, Karasik, D, Khaw, K-T, Kiel, DP, Kilpelaeinen, TO, Kolcic, I, Kraft, P, Launer, LJ, Laven, JSE, Li, S, Liu, J, Levy, D, Martin, NG, McArdle, WL, Melbye, M, Mooser, V, Murray, JC, Murray, SS, Nalls, MA, Navarro, P, Nelis, M, Ness, AR, Northstone, K, Oostra, BA, Peacock, M, Palmer, LJ, Palotie, A, Pare, G, Parker, AN, Pedersen, NL, Peltonen, L, Pennell, CE, Pharoah, P, Polasek, O, Plump, AS, Pouta, A, Porcu, E, Rafnar, T, Rice, JP, Ring, SM, Rivadeneira, F, Rudan, I, Sala, C, Salomaa, V, Sanna, S, Schlessinger, D, Schork, NJ, Scuteri, A, Segre, AV, Shuldiner, AR, Soranzo, N, Sovio, U, Srinivasan, SR, Strachan, DP, Tammesoo, M-L, Tikkanen, E, Toniolo, D, Tsui, K, Tryggvadottir, L, Tyrer, J, Uda, M, van Dam, RM, van Meurs, JBJ, Vollenweider, P, Waeber, G, Wareham, NJ, Waterworth, DM, Weedon, MN, Wichmann, HE, Willemsen, G, Wilson, JF, Wright, AF, Young, L, Zhai, G, Zhuang, WV, Bierut, LJ, Boomsma, DI, Boyd, HA, Crisponi, L, Demerath, EW, van Duijn, CM, Econs, MJ, Harris, TB, Hunter, DJ, Loos, RJF, Metspalu, A, Montgomery, GW, Ridker, PM, Spector, TD, Streeten, EA, Stefansson, K, Thorsteinsdottir, U, Uitterlinden, AG, Widen, E, Murabito, JM, Ong, KK & Murray, A 2010, 'Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies', Nature Genetics, vol. 42, no. 12, pp. 1077 - U73. https://doi.org/10.1038/ng.714

TY - JOUR

T1 - Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

AU - Elks, Cathy E.

AU - Perry, John R. B.

AU - Sulem, Patrick

AU - Chasman, Daniel I.

AU - Franceschini, Nora

AU - He, Chunyan

AU - Lunetta, Kathryn L.

AU - Visser, Jenny A.

AU - Byrne, Enda M.

AU - Cousminer, Diana L.

AU - Gudbjartsson, Daniel F.

AU - Esko, Tonu

AU - Feenstra, Bjarke

AU - Hottenga, Jouke-Jan

AU - Koller, Daniel L.

AU - Kutalik, Zoltan

AU - Lin, Peng

AU - Mangino, Massimo

AU - Marongiu, Mara

AU - McArdle, Patrick F.

AU - Smith, Albert V.

AU - Stolk, Lisette

AU - Van Wingerden, Sophie H.

AU - Zhao, Jing Hua

AU - Albrecht, Eva

AU - Corre, Tanguy

AU - Ingelsson, Erik

AU - Hayward, Caroline

AU - Magnusson, Patrik K. E.

AU - Smith, Erin N.

AU - Ulivi, Shelia

AU - Warrington, Nicole M.

AU - Zgaga, Lina

AU - Alavere, Helen

AU - Amin, Najaf

AU - Aspelund, Thor

AU - Bandinelli, Stefania

AU - Barroso, Ines

AU - Berenson, Gerald S.

AU - Bergmann, Sven

AU - Blackburn, Hannah

AU - Boerwinkle, Eric

AU - Buring, Julie E.

AU - Busonero, Fabio

AU - Campbell, Harry

AU - Chanock, Stephen J.

AU - Chen, Wei

AU - Cornelis, Marilyn C.

AU - Couper, David

AU - Coviello, Andrea D.

AU - d'Adamo, Pio

AU - de Faire, Ulf

AU - de Geus, Eco J. C.

AU - Deloukas, Panos

AU - Doering, Angela

AU - Smith, George Davey

AU - Easton, Douglas F.

AU - Eiriksdottir, Gudny

AU - Emilsson, Valur

AU - Eriksson, Johan

AU - Ferrucci, Luigi

AU - Folsom, Aaron R.

AU - Foroud, Tatiana

AU - Garcia, Melissa

AU - Gasparini, Paolo

AU - Geller, Frank

AU - Gieger, Christian

AU - Gudnason, Vilmundur

AU - Hall, Per

AU - Hankinson, Susan E.

AU - Ferreli, Liana

AU - Heath, Andrew C.

AU - Hernandez, Dena G.

AU - Hofman, Albert

AU - Hu, Frank B.

AU - Illig, Thomas

AU - Jaervelin, Marjo-Riitta

AU - Johnson, Andrew D.

AU - Karasik, David

AU - Khaw, Kay-Tee

AU - Kiel, Douglas P.

AU - Kilpelaeinen, Tuomas O.

AU - Kolcic, Ivana

AU - Kraft, Peter

AU - Launer, Lenore J.

AU - Laven, Joop S. E.

AU - Li, Shengxu

AU - Liu, Jianjun

AU - Levy, Daniel

AU - Martin, Nicholas G.

AU - McArdle, Wendy L.

AU - Melbye, Mads

AU - Mooser, Vincent

AU - Murray, Jeffrey C.

AU - Murray, Sarah S.

AU - Nalls, Michael A.

AU - Navarro, Pau

AU - Nelis, Mari

AU - Ness, Andrew R.

AU - Northstone, Kate

AU - Oostra, Ben A.

AU - Peacock, Munro

AU - Palmer, Lyle J.

AU - Palotie, Aarno

AU - Pare, Guillaume

AU - Parker, Alex N.

AU - Pedersen, Nancy L.

AU - Peltonen, Leena

AU - Pennell, Craig E.

AU - Pharoah, Paul

AU - Polasek, Ozren

AU - Plump, Andrew S.

AU - Pouta, Anneli

AU - Porcu, Eleonora

AU - Rafnar, Thorunn

AU - Rice, John P.

AU - Ring, Susan M.

AU - Rivadeneira, Fernando

AU - Rudan, Igor

AU - Sala, Cinzia

AU - Salomaa, Veikko

AU - Sanna, Serena

AU - Schlessinger, David

AU - Schork, Nicholas J.

AU - Scuteri, Angelo

AU - Segre, Ayellet V.

AU - Shuldiner, Alan R.

AU - Soranzo, Nicole

AU - Sovio, Ulla

AU - Srinivasan, Sathanur R.

AU - Strachan, David P.

AU - Tammesoo, Mar-Liis

AU - Tikkanen, Emmi

AU - Toniolo, Daniela

AU - Tsui, Kim

AU - Tryggvadottir, Laufey

AU - Tyrer, Jonathon

AU - Uda, Manuela

AU - van Dam, Rob M.

AU - van Meurs, Joyce B. J.

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Wareham, Nicholas J.

AU - Waterworth, Dawn M.

AU - Weedon, Michael N.

AU - Wichmann, H. Erich

AU - Willemsen, Gonneke

AU - Wilson, James F.

AU - Wright, Alan F.

AU - Young, Lauren

AU - Zhai, Guangju

AU - Zhuang, Wei Vivian

AU - Bierut, Laura J.

AU - Boomsma, Dorret I.

AU - Boyd, Heather A.

AU - Crisponi, Laura

AU - Demerath, Ellen W.

AU - van Duijn, Cornelia M.

AU - Econs, Michael J.

AU - Harris, Tamara B.

AU - Hunter, David J.

AU - Loos, Ruth J. F.

AU - Metspalu, Andres

AU - Montgomery, Grant W.

AU - Ridker, Paul M.

AU - Spector, Tim D.

AU - Streeten, Elizabeth A.

AU - Stefansson, Kari

AU - Thorsteinsdottir, Unnur

AU - Uitterlinden, Andre G.

AU - Widen, Elisabeth

AU - Murabito, Joanne M.

AU - Ong, Ken K.

AU - Murray, Anna

PY - 2010/12

Y1 - 2010/12

N2 - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P <5 x 10(-8)) and found suggestive evidence for a further 10 loci (P <1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

AB - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(-33)), we identified 30 new menarche loci (all P <5 x 10(-8)) and found suggestive evidence for a further 10 loci (P <1.9 x 10(-6)). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

U2 - 10.1038/ng.714

DO - 10.1038/ng.714

M3 - Article

SN - 1546-1718

VL - 42

SP - 1077 - U73

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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