King's College London

Research portal

Threat, Hostility, and Violence in Childhood and Later Psychotic Disorder

Research output: Contribution to journalArticle

Original languageEnglish
JournalBritish Journal of Psychiatry
Publication statusAccepted/In press - 5 Jun 2020

King's Authors

Abstract

Background 
A growing body of research suggests that childhood adversities are associated with later psychosis, broadly defined. However, there remain several gaps and unanswered questions. Most studies are of low-level psychotic experiences and findings cannot necessarily be extrapolated to psychotic disorders. Further, few studies have examined the effects of more fine-grained dimensions of adversity, e.g., type, timing, and severity.
Aims 
Using detailed data from the Childhood Adversity and Psychosis Study (CAPsy), we sought to address these gaps and examine in detail associations between a range of childhood adversities and psychotic disorder.
Method 
CAPsy is population-based first episode psychosis case-control study in the UK. In a sample of 374 cases and 301 controls, we collected extensive data on childhood adversities, in particular household discord, various forms of abuse, and bullying, and putative confounders, including family history of psychotic disorder, using validated, semi-structured instruments.
Results 
We found strong evidence that all forms of childhood adversity were associated with around a two- to four-fold increased odds of psychotic disorder and that exposure to multiple adversities was associated with a linear increase in odds. We further found that severe forms of adversity, i.e. involving threat, hostility, and violence, were most strongly associated with increased odds of disorder. More tentatively, we found that some adversities (e.g., bullying, sexual abuse), were more strongly associated with psychotic disorder if first occurrence was in adolescence.

Conclusion 
Our findings extend previous research on childhood adversity and suggest a degree of specificity for severe adversities involving threat, hostility, and violence.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454