Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life

S. R. Cox*, M. A. Harris, S. J. Ritchie, C. R. Buchanan, M. C. Valdés Hernández, J. Corley, A. M. Taylor, J. W. Madole, S. E. Harris, H. C. Whalley, A. M. McIntosh, T. C. Russ, M. E. Bastin, J. M. Wardlaw, I. J. Deary, E. M. Tucker-Drob

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Different brain regions can be grouped together, based on cross-sectional correlations among their cortical characteristics; this patterning has been used to make inferences about ageing processes. However, cross-sectional brain data conflate information on ageing with patterns that are present throughout life. We characterised brain cortical ageing across the eighth decade of life in a longitudinal ageing cohort, at ages ~73, ~76, and ~79 years, with a total of 1376 MRI scans. Volumetric changes among cortical regions of interest (ROIs) were more strongly correlated (average r = 0.805, SD = 0.252) than were cross-sectional volumes of the same ROIs (average r = 0.350, SD = 0.178). We identified a broad, cortex-wide, dimension of atrophy that explained 66% of the variance in longitudinal changes across the cortex. Our modelling also discovered more specific fronto-temporal and occipito-parietal dimensions that were orthogonal to the general factor and together explained an additional 20% of the variance. The general factor was associated with declines in general cognitive ability (r = 0.431, p < 0.001) and in the domains of visuospatial ability (r = 0.415, p = 0.002), processing speed (r = 0.383, p < 0.001) and memory (r = 0.372, p < 0.001). Individual differences in brain cortical atrophy with ageing are manifest across three broad dimensions of the cerebral cortex, the most general of which is linked with cognitive declines across domains. Longitudinal approaches are invaluable for distinguishing lifelong patterns of brain-behaviour associations from patterns that are specific to aging.

Original languageEnglish
Pages (from-to)2651-2662
Number of pages12
JournalMolecular Psychiatry
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2021

Fingerprint

Dive into the research topics of 'Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life'. Together they form a unique fingerprint.

Cite this