Thymosin beta 4 facilitates epicardial neovascularization of the injured adult heart

Nicola Smart, Catherine A. Risebro, James E. Clark, Elisabeth Ehler, Lucile Miquerol, Alex Rossdeutsch, Michael S. Marber, Paul R. Riley

Research output: Chapter in Book/Report/Conference proceedingConference paper

87 Citations (Scopus)

Abstract

Ischemic heart disease complicated by coronary artery occlusion causes myocardial infarction (MI), which is the major cause of morbidity and mortality in humans (http://www.who.int/cardiovascular_diseases/resources/atlas/en/index.html). After MI the human heart has an impaired capacity to regenerate and, despite the high prevalence of cardiovascular disease worldwide, there is currently only limited insight into how to stimulate repair of the injured adult heart from its component parts. Efficient cardiac regeneration requires the replacement of lost cardiomyocytes, formation of new coronary blood vessels, and appropriate modulation of inflammation to prevent maladaptive remodeling, fibrosis/scarring, and consequent cardiac dysfunction. Here we show that thymosin 134 (T beta 4) promotes new vasculature in both the intact and injured mammalian heart. We demonstrate that limited EPDC-derived endothelial-restricted neovascularization constitutes suboptimal "endogenous repair," following injury, which is significantly augmented by T beta 4 to increase and stabilize the vascular plexus via collateral vessel growth. As such, we identify T beta 4 as a facilitator of cardiac neovascularization and highlight adult EPDCs as resident progenitors which, when instructed by T beta 4, have the capacity to sustain the myocardium after ischemic damage.
Original languageEnglish
Title of host publicationThymosins in Health and Disease: 2nd International Symposium
EditorsDouglas Braaten
PublisherBlackwell Publishing
Pages97-104
Number of pages8
Volume1194
ISBN (Print)978-1-57331-801-3
DOIs
Publication statusPublished - May 2010
Event2nd International Symposium on Thymosins in Health and Disease - Catania, Italy
Duration: 30 Sept 20092 Oct 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Electronic)1749-6632

Conference

Conference2nd International Symposium on Thymosins in Health and Disease
Country/TerritoryItaly
CityCatania
Period30/09/20092/10/2009

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