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TIGIT blockade repolarizes AML-associated TIGIT+M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis

  • Franziska Brauneck*
  • , Brit Fischer
  • , Marius Witt
  • , Jana Muschhammer
  • , Jennyfer Oelrich
  • , Pedro Henrique da Costa Avelar
  • , Sophia Tsoka
  • , Lars Bullinger
  • , Elisa Seubert
  • , Daniel J Smit
  • , Carsten Bokemeyer
  • , Christin Ackermann
  • , Jasmin Wellbrock
  • , Friedrich Haag
  • , Walter Fiedler
  • *Corresponding author for this work
  • Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Department of Hematology, Oncology and Tumor Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
  • Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Department of Oncology, Haematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

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83 Citations (Scopus)

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