TIME TRENDS IN SURVIVAL AFTER FIRST PRIMARY INTRACEREBRAL HAEMORRHAGE AND ISCHAEMIC STROKE BETWEEN 2000 AND 2015 IN THE SOUTH LONDON STROKE REGISTER(SLSR)

TY - JOUR

T1 - TIME TRENDS IN SURVIVAL AFTER FIRST PRIMARY INTRACEREBRAL HAEMORRHAGE AND ISCHAEMIC STROKE BETWEEN 2000 AND 2015 IN THE SOUTH LONDON STROKE REGISTER(SLSR)

AU - Li, Xianqi

AU - Wolfe, Charles

AU - Wang, Yanzhong

PY - 2022/5/3

Y1 - 2022/5/3

N2 - Background and aims: Survival after stroke is an important factor to monitor stroke burden. Recent data on survival by stroke subtype in the general population is limited. This study estimates time trends in survival of first-ever primary intracerebral haemorrhage(PICH) and ischaemic stroke(IS) over a 16-year period.Methods: Population-based case ascertainment of PICH and IS was conducted, and all participants who had their first-ever ICH and IS between 2000 and 2015 were identified. We assessed time trends in survival across 4 time periods (2000–2003; 2004–2007; 2008–2011, 2012-2015) using proportional-hazards Cox modelling, adjusted for demography, pre-stroke factors, case-mix variables, and processes of care. Kaplan-Meier curves were performed.Results: In total, 528 with PICH and 3128 patients with IS were registered. In the PICH group, the mean age was 64.4 years, 57.8% were male. Compared with the earliest study period (2000–2003), mortality rates remained unchanged in 2012–2015 (hazard ratio[HR]: 0.951 [95% CI, 0.347–2.607]; P=0.92). No changes were observed in both sexes and in patients aged >= 65 years (HR per year 0.938; 95%CI 0.824- 1.067). In the IS group, the mean age was 65.5 years, 56.6% were male. The adjusted overall mortality decreased by 24% (HR per year: 0.976; 95% CI 0.959-0.993) between 2000-2003 and 2012- 2015. Survival improvements were also observed in both sexes and patients aged >= 65 years (HR per year 0.975; 95%CI 0.959- 0.992).Conclusions: Survival after IS has improved over the past decades, while no change was observed in survival following PICH.

AB - Background and aims: Survival after stroke is an important factor to monitor stroke burden. Recent data on survival by stroke subtype in the general population is limited. This study estimates time trends in survival of first-ever primary intracerebral haemorrhage(PICH) and ischaemic stroke(IS) over a 16-year period.Methods: Population-based case ascertainment of PICH and IS was conducted, and all participants who had their first-ever ICH and IS between 2000 and 2015 were identified. We assessed time trends in survival across 4 time periods (2000–2003; 2004–2007; 2008–2011, 2012-2015) using proportional-hazards Cox modelling, adjusted for demography, pre-stroke factors, case-mix variables, and processes of care. Kaplan-Meier curves were performed.Results: In total, 528 with PICH and 3128 patients with IS were registered. In the PICH group, the mean age was 64.4 years, 57.8% were male. Compared with the earliest study period (2000–2003), mortality rates remained unchanged in 2012–2015 (hazard ratio[HR]: 0.951 [95% CI, 0.347–2.607]; P=0.92). No changes were observed in both sexes and in patients aged >= 65 years (HR per year 0.938; 95%CI 0.824- 1.067). In the IS group, the mean age was 65.5 years, 56.6% were male. The adjusted overall mortality decreased by 24% (HR per year: 0.976; 95% CI 0.959-0.993) between 2000-2003 and 2012- 2015. Survival improvements were also observed in both sexes and patients aged >= 65 years (HR per year 0.975; 95%CI 0.959- 0.992).Conclusions: Survival after IS has improved over the past decades, while no change was observed in survival following PICH.

U2 - 10.1177/23969873221087559

DO - 10.1177/23969873221087559

M3 - Meeting abstract

SN - 2396-9873

VL - 7

SP - 389

EP - 389

JO - European Stroke Journal

JF - European Stroke Journal

IS - 1_suppl

M1 - P0656/1328

ER -