Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness

Miguel Germán Borda; Daniel Ferreira; Per Selnes; Diego Alejandro Tovar-Rios; Alberto Jaramillo-Jiménez; Bjørn Eivind Kirsebom; Elkin Garcia-Cifuentes; Turi O. Dalaker; Ketil Oppedal; Hogne Sønnesyn; Tormod Fladby; Dag Aarsland

doi:10.1159/000522094

Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness

Miguel Germán Borda^*, Daniel Ferreira, Per Selnes, Diego Alejandro Tovar-Rios, Alberto Jaramillo-Jiménez, Bjørn Eivind Kirsebom, Elkin Garcia-Cifuentes, Turi O. Dalaker, Ketil Oppedal, Hogne Sønnesyn, Tormod Fladby, Dag Aarsland

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive decline (SCD). Methods: This is a longitudinal analysis of the Dementia Disease Initiation Study, a prospective, community-based, cohort study from Norway, designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD and healthy controls (HC). The main studied variables were the TUG test and cognition as measured by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease memory composite score. Additionally, we investigated the cross-sectional association of brain morphology with the TUG using 1.5T-MRI. Results: The sample included 45 participants (SCD = 21, HC = 24) followed during a mean time of 1.50 ± 0.70 years. At baseline, the cognitive performance did not differ between the groups, but TUG was longer in SCD. Slower baseline TUG was associated with a faster cognitive decline in both groups and it was also associated with reduced cortical thickness especially in motor, executive, associative, and somatosensory cortical regions in people with SCD. Discussion/Conclusion: TUG predicted cognitive change in individuals with SCD, and there was a negative association between TUG and cortical thickness. TUG is a promising cheap and noninvasive marker of early cognitive decline and may help initiate interventions in individuals who have an increased risk of dementia.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Dementia and Geriatric Cognitive Disorders
Volume	51
Issue number	1
Early online date	25 Mar 2022
DOIs	https://doi.org/10.1159/000522094
Publication status	Published - 1 Apr 2022

Keywords

Dementia
Gait
Neuroimaging
Physical performance
Predementia

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10.1159/000522094

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Borda, M. G., Ferreira, D., Selnes, P., Tovar-Rios, D. A., Jaramillo-Jiménez, A., Kirsebom, B. E., Garcia-Cifuentes, E., Dalaker, T. O., Oppedal, K., Sønnesyn, H., Fladby, T., & Aarsland, D. (2022). Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness. Dementia and Geriatric Cognitive Disorders, 51(1), 63-72. https://doi.org/10.1159/000522094

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title = "Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness",

abstract = "Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive decline (SCD). Methods: This is a longitudinal analysis of the Dementia Disease Initiation Study, a prospective, community-based, cohort study from Norway, designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD and healthy controls (HC). The main studied variables were the TUG test and cognition as measured by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease memory composite score. Additionally, we investigated the cross-sectional association of brain morphology with the TUG using 1.5T-MRI. Results: The sample included 45 participants (SCD = 21, HC = 24) followed during a mean time of 1.50 ± 0.70 years. At baseline, the cognitive performance did not differ between the groups, but TUG was longer in SCD. Slower baseline TUG was associated with a faster cognitive decline in both groups and it was also associated with reduced cortical thickness especially in motor, executive, associative, and somatosensory cortical regions in people with SCD. Discussion/Conclusion: TUG predicted cognitive change in individuals with SCD, and there was a negative association between TUG and cortical thickness. TUG is a promising cheap and noninvasive marker of early cognitive decline and may help initiate interventions in individuals who have an increased risk of dementia. ",

keywords = "Dementia, Gait, Neuroimaging, Physical performance, Predementia",

author = "Borda, {Miguel Germ{\'a}n} and Daniel Ferreira and Per Selnes and Tovar-Rios, {Diego Alejandro} and Alberto Jaramillo-Jim{\'e}nez and Kirsebom, {Bj{\o}rn Eivind} and Elkin Garcia-Cifuentes and Dalaker, {Turi O.} and Ketil Oppedal and Hogne S{\o}nnesyn and Tormod Fladby and Dag Aarsland",

note = "Funding Information: The project was supported by the Norwegian Research Council, NASATS (DDI), and the JPND (APGeM), and funding was received from the regional health authorities (Helse S{\o}r-{\O}st and Helse vest). The project was also funded by the National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London. The views expressed are those of the author(s) and not necessarily of the NHS, the National Institute for Health Research, or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = apr,

day = "1",

doi = "10.1159/000522094",

language = "English",

volume = "51",

pages = "63--72",

journal = "Dementia and Geriatric Cognitive Disorders",

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Borda, MG, Ferreira, D, Selnes, P, Tovar-Rios, DA, Jaramillo-Jiménez, A, Kirsebom, BE, Garcia-Cifuentes, E, Dalaker, TO, Oppedal, K, Sønnesyn, H, Fladby, T & Aarsland, D 2022, 'Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness', Dementia and Geriatric Cognitive Disorders, vol. 51, no. 1, pp. 63-72. https://doi.org/10.1159/000522094

TY - JOUR

T1 - Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness

AU - Borda, Miguel Germán

AU - Ferreira, Daniel

AU - Selnes, Per

AU - Tovar-Rios, Diego Alejandro

AU - Jaramillo-Jiménez, Alberto

AU - Kirsebom, Bjørn Eivind

AU - Garcia-Cifuentes, Elkin

AU - Dalaker, Turi O.

AU - Oppedal, Ketil

AU - Sønnesyn, Hogne

AU - Fladby, Tormod

AU - Aarsland, Dag

N1 - Funding Information: The project was supported by the Norwegian Research Council, NASATS (DDI), and the JPND (APGeM), and funding was received from the regional health authorities (Helse Sør-Øst and Helse vest). The project was also funded by the National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily of the NHS, the National Institute for Health Research, or the Department of Health and Social Care. Publisher Copyright: © 2022

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive decline (SCD). Methods: This is a longitudinal analysis of the Dementia Disease Initiation Study, a prospective, community-based, cohort study from Norway, designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD and healthy controls (HC). The main studied variables were the TUG test and cognition as measured by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease memory composite score. Additionally, we investigated the cross-sectional association of brain morphology with the TUG using 1.5T-MRI. Results: The sample included 45 participants (SCD = 21, HC = 24) followed during a mean time of 1.50 ± 0.70 years. At baseline, the cognitive performance did not differ between the groups, but TUG was longer in SCD. Slower baseline TUG was associated with a faster cognitive decline in both groups and it was also associated with reduced cortical thickness especially in motor, executive, associative, and somatosensory cortical regions in people with SCD. Discussion/Conclusion: TUG predicted cognitive change in individuals with SCD, and there was a negative association between TUG and cortical thickness. TUG is a promising cheap and noninvasive marker of early cognitive decline and may help initiate interventions in individuals who have an increased risk of dementia.

AB - Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitive decline in people with subjective cognitive decline (SCD). Methods: This is a longitudinal analysis of the Dementia Disease Initiation Study, a prospective, community-based, cohort study from Norway, designed to investigate early markers of cognitive impairment and dementia. Participants were classified as SCD and healthy controls (HC). The main studied variables were the TUG test and cognition as measured by the Mini-Mental State Examination and the Consortium to Establish a Registry for Alzheimer's Disease memory composite score. Additionally, we investigated the cross-sectional association of brain morphology with the TUG using 1.5T-MRI. Results: The sample included 45 participants (SCD = 21, HC = 24) followed during a mean time of 1.50 ± 0.70 years. At baseline, the cognitive performance did not differ between the groups, but TUG was longer in SCD. Slower baseline TUG was associated with a faster cognitive decline in both groups and it was also associated with reduced cortical thickness especially in motor, executive, associative, and somatosensory cortical regions in people with SCD. Discussion/Conclusion: TUG predicted cognitive change in individuals with SCD, and there was a negative association between TUG and cortical thickness. TUG is a promising cheap and noninvasive marker of early cognitive decline and may help initiate interventions in individuals who have an increased risk of dementia.

KW - Dementia

KW - Gait

KW - Neuroimaging

KW - Physical performance

KW - Predementia

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U2 - 10.1159/000522094

DO - 10.1159/000522094

M3 - Article

C2 - 35339996

AN - SCOPUS:85128528811

SN - 1420-8008

VL - 51

SP - 63

EP - 72

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 1

ER -

Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness

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Keywords

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